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Titolo:
THE NEURONAL TRANSPORT MECHANISM FOR NORADRENALINE IS NOT INFLUENCED BY THE ATP ANALOG ATP-GAMMA-S
Autore:
GLIESE M; BABINEBELL J; SCHOMIG E; RUSS H;
Indirizzi:
UNIV REGENSBURG,DEPT NEUROSURG,FRANZ JOSEF STRAUSS ALLEE 11 D-93042 REGENSBURG GERMANY UNIV WURZBURG,DEPT PHARMACOL D-97078 WURZBURG GERMANY
Titolo Testata:
Life sciences
fascicolo: 15, volume: 55, anno: 1994,
pagine: 267 - 270
SICI:
0024-3205(1994)55:15<267:TNTMFN>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHEOCHROMOCYTOMA CELLS; PLASMA-MEMBRANE;
Keywords:
NORADRENALINE TRANSPORT; ATP; ATP-GAMMA-S;
Tipo documento:
Letter
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
M. Gliese et al., "THE NEURONAL TRANSPORT MECHANISM FOR NORADRENALINE IS NOT INFLUENCED BY THE ATP ANALOG ATP-GAMMA-S", Life sciences, 55(15), 1994, pp. 267-270

Abstract

Noradrenaline is taken up in noradrenergic neurones via a desipramine-sensitive transport system (uptake(1)). There are reports which describe the activity of uptake(1) being increased by extracellular ATP andATP gamma S. This was attributed to a protein kinase-mediated mechanism. We reevaluated this phenomenon since a modulation of uptake(1) by extracellular ATP would be of great physiological relevance. In clonalrat pheochromocytoma cells (PC12) we determined the kinetic parameters, K-m and V-max, of noradrenaline transport in the absence and presence of ATP gamma S. The addition of 0.1 mu mol/L ATP gamma S had no effect on initial rates of specific noradrenaline transport. Only a slightly increased non-specific noradrenaline flux in the presence of ATP gamma S could be observed. On the basis of our results, there is no evidence for the modulation of the uptake(1) carrier by ATP gamma S.

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Documento generato il 12/07/20 alle ore 03:24:07