Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Histologic changes in three explanted native cardiac valves following use of fenfluramines
Autore:
Steffee, CH; Singh, HK; Chitwood, WR;
Indirizzi:
E Carolina Univ, Sch Med, Dept Pathol & Lab Med, Greenville, NC 27858 USA E Carolina Univ Greenville NC USA 27858 Lab Med, Greenville, NC 27858 USA E Carolina Univ, Sch Med, Dept Surg, Sect Cardiothorac Surg, Greenville, NC 27858 USA E Carolina Univ Greenville NC USA 27858 ac Surg, Greenville, NC 27858 USA
Titolo Testata:
CARDIOVASCULAR PATHOLOGY
fascicolo: 5, volume: 8, anno: 1999,
pagine: 245 - 253
SICI:
1054-8807(199909/10)8:5<245:HCITEN>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
VALVULAR HEART-DISEASE; APPETITE-SUPPRESSANT DRUGS; PRIMARY PULMONARY-HYPERTENSION; RHEUMATIC MITRAL-VALVE; OBESE PATIENTS; PHENTERMINE; RISK; ECHOCARDIOGRAPHY; DEXFENFLURAMINE; REGURGITATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Steffee, CH E Carolina Univ, Sch Med, Dept Pathol & Lab Med, Brody 7s-10, Greenville, NC 27858 USA E Carolina Univ Brody 7s-10 Greenville NC USA 27858 27858 USA
Citazione:
C.H. Steffee et al., "Histologic changes in three explanted native cardiac valves following use of fenfluramines", CARDIO PATH, 8(5), 1999, pp. 245-253

Abstract

Use of fenfluramines, either alone or co-administered with phentermine ("fen-phen") as anorexic agents in obesity, has been associated with the development of clinically significant cardiac valve disease. We present the macroscopic and histologic findings in cardiac valves explanted from three patients who presented with valvular disease after fenfluramine or fenfluramine-phentermine use and underwent single valve replacement surgery. Paraffin sections were prepared with hematoxylin and eosin, trichrome, elastic-van Gieson, and Giemsa stains, as well as immunostains using antibody to CD3 and CD20. All three patients (two females, ages 37 and 43, and a 49-year-old male) developed progressively symptomatic mitral (2 patients) or aortic (1 patient) valvular insufficiency following dexfenfluramine (2 patients) or fenfluramine-phentermine (1 patient) use. Macroscopic changes included irregular leaflet thickening, accompanied by chordal fusion in the mitral valves, but without vegetations, commissural fusion, or evidence of annular dilation. Histologically, fibromyxoid plaques and nodules just below the valve surface, superficial to a generally intact elastic fiber layer, were associated with CDS-positive lymphocytes. Valves from all three patients had centralmyxoid degenerative changes, which were focal/mild in one mitral valve, diffuse/moderate in one mitral valve, and diffuse/marked in one aortic valve. Focal areas of superficial fibromyxoid change or intimal thickening may also be seen in cardiac valves from patients with drug-unrelated processes leading to symptomatic or asymptomatic valvulopathy. Therefore, when valve tissue is available for histopathologic examination, valvular disease can be attributed to use of fenfluramines only if the following criteria are satisfied: (i) the macroscopic and microscopic features are consistent with fenfluramine-related valvulopathy, (ii) clinical, echocardiographic, and intraoperative findings support the diagnosis, and (iii) the history of drug exposure predates the development or exacerbation of valvular dysfunction. (C) 1999 by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:26:00