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Titolo:
Chandelier cells and epilepsy
Autore:
DeFelipe, J;
Indirizzi:
CSIC, Inst Cajal, E-28002 Madrid, Spain CSIC Madrid Spain E-28002CSIC, Inst Cajal, E-28002 Madrid, Spain
Titolo Testata:
BRAIN
, volume: 122, anno: 1999,
parte:, 10
pagine: 1807 - 1822
SICI:
0006-8950(199910)122:<1807:CCAE>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL-LOBE EPILEPSY; RAT FRONTAL-CORTEX; HUMAN EPILEPTOGENIC NEOCORTEX; MONKEY PREFRONTAL CORTEX; CALCIUM-BINDING PROTEINS; GAMMA-AMINOBUTYRIC-ACID; LOCAL CIRCUIT NEURONS; SENSORY-MOTOR CORTEX; AXON INITIAL SEGMENT; CAT VISUAL-CORTEX;
Keywords:
human; cortical circuitry; interneurons; parvalbumin; neuronal loss;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
132
Recensione:
Indirizzi per estratti:
Indirizzo: DeFelipe, J CSIC, Inst Cajal, Avenida Dr Arce 37, E-28002 Madrid, Spain CSIC Avenida Dr Arce 37 Madrid Spain E-28002 02 Madrid, Spain
Citazione:
J. DeFelipe, "Chandelier cells and epilepsy", BRAIN, 122, 1999, pp. 1807-1822

Abstract

The main goal of this article is to review certain aspects of the circuitry of the human cerebral cortex that may be particularly relevant for the development, maintenance or spread of seizures. There are a number of different structural abnormalities that are commonly found in the cortex of epileptic patients, but these abnormalities do not appear to be intrinsically epileptogenic, since some patients displaying them are epileptic (after variable delays) whereas others are not. Therefore, cortical circuits in an affected brain may undergo a series of changes that finally cause epilepsy. In this article, it is proposed that the chandelier cell, which is considered to be the most powerful cortical GABAergic inhibitory interneuron, is probably a key component of cortical circuits in the establishment of human intractable temporal lobe epilepsy. These cells (among other types) have been found to be lost or reduced at epileptic foci in both experimental animals and epileptic patients, A hypothesis is presented by which the normal variability in the number of interneurons might explain the predisposition of someindividuals to develop epilepsy more than others as a result of a lesion or other precipitating factors that lead to loss of neurons. The sources of GABAergic input on dendrites and somata of cortical pyramidal cells originate from many and diverse types of interneurons but, at the level of the axon initial segment of these cells, all synapses come from a few chandelier cells (five or less). Loss of one class of interneurons ending on soma and dendrites might have relatively little impact on the inhibitory control of the pyramidal cell, However, if chandelier cells were affected, it would have serious consequences for the inhibitory control of the pyramidal cells. Evidence suggests that the loss of chandelier cells may be nonspecific and that when this occurs epilepsy may develop. Therefore, these cells might represent a key component in the aetiology of human temporal lobe epilepsy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 22:42:25