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Titolo:
Behavioral and neurochemical differences between Fischer 344 and Harlan-Wistar rats raised identically
Autore:
Rex, A; Voigt, JP; Fink, H;
Indirizzi:
Humboldt Univ, Fac Med Charite, Inst Pharmacol & Toxicol, D-10098 Berlin, Germany Humboldt Univ Berlin Germany D-10098 & Toxicol, D-10098 Berlin, Germany Free Univ Berlin, Sch Vet Med, Inst Pharmacol & Toxicol, D-14195 Berlin, Germany Free Univ Berlin Berlin Germany D-14195 Toxicol, D-14195 Berlin, Germany
Titolo Testata:
BEHAVIOR GENETICS
fascicolo: 3, volume: 29, anno: 1999,
pagine: 187 - 192
SICI:
0001-8244(199905)29:3<187:BANDBF>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED PLUS-MAZE; SOCIAL-INTERACTION; SEROTONIN RELEASE; INBRED STRAINS; ANIMAL-MODELS; GUINEA-PIG; X-MAZE; ANXIETY; VALIDATION; STRESS;
Keywords:
anxiety; genetic differences; microdialysis; serotonin; elevated plus-maze test; black-and-white box test; social interaction test; modified open-field test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Rex, A Humboldt Univ, Fac Med Charite, Inst Pharmacol & Toxicol, Clara Zetkin Str94, D-10098 Berlin, Germany Humboldt Univ Clara Zetkin Str 94 Berlin Germany D-10098 , Germany
Citazione:
A. Rex et al., "Behavioral and neurochemical differences between Fischer 344 and Harlan-Wistar rats raised identically", BEHAV GENET, 29(3), 1999, pp. 187-192

Abstract

Inbred Fisher 344 and outbred Harlan-Wistar rats were compared in the elevated plus maze, the black-and-white box, the social interaction test, and amodified open-field test, to assess the contribution of genetic factors toaversion-motivated behavior. All animals used were born and raised under identical conditions. Compared to the Wistar rats, the Fischer rats displayed a more pronounced fearful behavior in all tests. In a separate microdialysis study, the relationship between behavioral variations to biochemical differences was assessed, with serotonin (5-HT) release in the ventral hippocampus being measured during the elevated plus-maze test. Exposure to the elevated plus-maze induced an increase in hippocampal 5-HT in the (more anxious) Fischer rats but not in the (less anxious) Wistar rats. The results confirm the influence of genetic factors on emotionality in rats and demonstrate a close, although not simple, relationship between the serotonergic system and "anxiety-related" behavior.

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Documento generato il 04/04/20 alle ore 08:34:37