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Titolo:
A note on the power provided by sibships of sizes 2, 3, and 4 in genetic covariance modeling of a codominant QTL
Autore:
Dolan, CV; Boomsma, DI; Neale, MC;
Indirizzi:
Univ Amsterdam, Dept Psychol, NL-1018 WB Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1018 WB B Amsterdam, Netherlands Vrije Univ Amsterdam, Dept Biol Psychol, NL-1081 HV Amsterdam, NetherlandsVrije Univ Amsterdam Amsterdam Netherlands NL-1081 HV erdam, Netherlands Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Richmond, VA 23219 USA Virginia Commonwealth Univ Richmond VA USA 23219 , Richmond, VA 23219 USA
Titolo Testata:
BEHAVIOR GENETICS
fascicolo: 3, volume: 29, anno: 1999,
pagine: 163 - 170
SICI:
0001-8244(199905)29:3<163:ANOTPP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE TRAIT LOCI; DISCORDANT SIB PAIRS; LINKAGE ANALYSIS; SELECTION; SAMPLES;
Keywords:
sibships; QTL; environmental effects; polygenic effects; covariance structures; power;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Dolan, CV Univ Amsterdam, Dept Psychol, Roetersstr 15, NL-1018 WB Amsterdam, Netherlands Univ Amsterdam Roetersstr 15 Amsterdam Netherlands NL-1018 WB s
Citazione:
C.V. Dolan et al., "A note on the power provided by sibships of sizes 2, 3, and 4 in genetic covariance modeling of a codominant QTL", BEHAV GENET, 29(3), 1999, pp. 163-170

Abstract

The contribution of size 3 and size 4 sibships to power in covariance structure modeling of a codominant QTL is investigated. Power calculations are based on the noncentral chi-square distribution. Sixteen sets of parameter values are considered. Results indicate that size 3 and size 4 sibships provided large increases in power over size 2 sibships. On average a size 3 (4) sibship is 3 (6 to 7) times as informative as a size 2 sibship. The increase in power does not depend on the specific effects sizes of the independent variables in the model. These findings extend results presented by Fulker and Cherny (1996) and Schork (1993). We consider the informativeness of the size 2, 3, and 4 sibships, which differ in the unique configuration of IBD sharing. Three of the 10 size 3 and 7 of the 36 size 4 sibships are particularly informative. The results presented concern random (unselective) sampling but do have implications for selective sampling.

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Documento generato il 16/02/20 alle ore 20:57:05