Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of perfusion mode on regional and global organ blood flow in a neonatal piglet model
Autore:
Undar, A; Masai, T; Yang, SQ; Goddard-Finegold, J; Frazier, OH; Fraser, CD;
Indirizzi:
Texas Childrens Hosp, Congenital Heart Surg Serv, Dept Surg, Baylor Coll Med, Houston, TX 77030 USA Texas Childrens Hosp Houston TX USA 77030 Coll Med, Houston, TX 77030 USA Texas Heart Inst, Cullen Cardiovasc Surg Res Labs, Houston, TX USA Texas Heart Inst Houston TX USA ardiovasc Surg Res Labs, Houston, TX USA
Titolo Testata:
ANNALS OF THORACIC SURGERY
fascicolo: 4, volume: 68, anno: 1999,
pagine: 1336 - 1342
SICI:
0003-4975(199910)68:4<1336:EOPMOR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEDIATRIC CARDIOPULMONARY BYPASS; CEREBRAL HEMODYNAMICS; CIRCULATORY ARREST; PULSATILE FLOW; SURGERY; SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Undar, A Texas Childrens Hosp, Congenital Heart Surg Serv, Dept Surg, Baylor Coll Med, 6621 Fannin St,MC 1-2285, Houston, TX 77030 USA Texas Childrens Hosp 6621 Fannin St,MC 1-2285 Houston TX USA 77030
Citazione:
A. Undar et al., "Effects of perfusion mode on regional and global organ blood flow in a neonatal piglet model", ANN THORAC, 68(4), 1999, pp. 1336-1342

Abstract

Background. Organ injury (brain, kidney, and heart) has been reported in up to 30% of pediatric open heart surgery patients after conventional hypothermic nonpulsatile cardiopulmonary bypass (CPB) support with or without deep hypothermic circulatory arrest (DHCA). The effects of pulsatile (with a Food and Drug Administration approved modified roller pump) versus nonpulsatile perfusion on regional and global cerebral, renal, and myocardial blood flow were investigated during and after CFB with 60 minutes of DHCA in a neonatal piglet model. Methods. Piglets, mean weight 3 kg, were used in both pulsatile (n = 7) and non-pulsatile (n = 7) groups. After initiation of CPB, all animals were subjected to hypothermia for 25 minutes, reducing the rectal temperatures to18 degrees C, 60 minutes of DHCA followed by 10 minutes of cold reperfusion and 40 minutes of rewarming with a pump flow of 150 mL/kg/min. During cooling and rewarming, alpha-stat acid-base management was used. Differently labeled radioactive microspheres were injected pre-CPB, on normothermic CPB,pre-DHCA, post-DHCA, and after CPB to measure the regional and global cerebral, renal, and myocardial blood flows. Results. Global cerebral blood flow was significantly higher in the pulsatile group compared to the nonpulsatile group at normothermic CPB (100.4 +/-6.3 mL/100 gm/min versus 70.2 +/- 8.1 mL/100 gm/min, p < 0.05) and pre-DHCA (77.2 +/- 5.2 mL/100 gm/min versus 56.1 +/- 6.7 mL/100 gm/min, p < 0.05). Blood now in cerebellum, basal ganglia, brain stem, and right and left cerebral hemispheres had an identical pattern with the global cerebral blood flow. Renal blood flow appeared higher in the pulsatile group compared to the non-pulsatile group during CPB, but the results were statistically significant only at post-CPB (94.8 +/- 9 mL/100 gm/min versus 22.5 +/- 22 mL/100 gm/min, p < 0.05). Pulsatile flow better maintained the myocardial blood flow compared to the nonpulsatile flow after CFB (316.6 +/- 45.5 mL/100 gm/min versus 188.2 +/- 19.5 mL/100 gm/min, p < 0.05). Conclusions. Pulsatile perfusion provides superior vital organ blood now compared to non-pulsatile perfusion in this model. (C) 1999 by The Society of Thoracic Surgeons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/12/18 alle ore 23:05:47