Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Development of spinal cord ischemia after clamping of noncritical segmental arteries in the pig
Autore:
de Haan, P; Kalkman, CJ; Meylaerts, SAG; Lips, J; Jacobs, MJHM;
Indirizzi:
Univ Amsterdam, Acad Hosp, Acad Med Ctr, Dept Anesthesiol, NL-1100 DD Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1100 DD D Amsterdam, Netherlands Univ Amsterdam, Acad Hosp, Acad Med Ctr, Dept Vasc Surg, NL-1100 DD Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1100 DD D Amsterdam, Netherlands
Titolo Testata:
ANNALS OF THORACIC SURGERY
fascicolo: 4, volume: 68, anno: 1999,
pagine: 1278 - 1284
SICI:
0003-4975(199910)68:4<1278:DOSCIA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW; PARAPLEGIA; OPERATIONS; ANEURYSMS; SURGERY; AORTA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: de Haan, P Univ Amsterdam, Acad Hosp, Acad Med Ctr, Dept Anesthesiol, Postbus 22660, NL-1100 DD Amsterdam, Netherlands Univ Amsterdam Postbus 22660 Amsterdam Netherlands NL-1100 DD
Citazione:
P. de Haan et al., "Development of spinal cord ischemia after clamping of noncritical segmental arteries in the pig", ANN THORAC, 68(4), 1999, pp. 1278-1284

Abstract

Background. Blood flow to the thoracolumbar spinal cord is thought to be critically dependent on the arteria radicularis magna. We investigated whether spinal cord blood supply becomes dependent on other, noncritical, segmental arteries if spinal cord perfusion pressure (SCPP) is decreased. The SCPP is equal to the mean arterial pressure (MAP) minus the cerebrospinal fluid (CSF) pressure (SCCP = MAP - CSF). Methods. The thoracoabdominal aorta was exposed in 10 pigs. Functional integrity of spinal cord motor pathways was assessed with myogenic motor-evoked potentials after transcranial electrical stimulation (tc-MEPs). Using this technique, a group of segmental arteries not critical for spinal ford blood supply was identified. Before, during, and after clamping of the noncritical segmental arteries, spinal cord ischemia was produced by decreasing SCPP by means of increasing CSF pressure, and the SCPP threshold at which tc-MEPs showed evidence of spinal cord ischemia was determined. Ischemic SCPP thresholds, obtained during and after clamping of the noncritical segmentalarteries, were compared with the ischemic threshold obtained before clamping (control value). Results. Before noncritical segmental arteries were clamped, ischemic tc-MEP changes occurred when the SCPP was below 15 +/- 5 (SD) mm Hg. With a total of 9 +/- 3 (SD) segmental arteries clamped, the ischemic SCPP threshold was 48 +/- 14 mm Hg (p < 0.01). After the release of all clamps, ischemia occurred at a SCPP of 15 +/- 5 (SD) mm Hg. Conclusions. In this porcine experiment, clamping of originally noncritical segmental arteries significantly reduced the tolerance of the spinal cordto a decrease in SCPP. (C) 1999 by The Society of Thoracic Surgeons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 13:35:30