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Titolo:
Development of eosinophilic airway inflammation and airway hyperresponsiveness requires interleutkin-5 but not immunoglobulin E or B lymphocytes
Autore:
Hamelmann, E; Takeda, K; Schwarze, J; Vella, AT; Irvin, CG; Gelfand, EW;
Indirizzi:
Natl Jewish Med & Res Ctr, Dept Pediat, Denver, CO 80260 USA Natl Jewish Med & Res Ctr Denver CO USA 80260 ediat, Denver, CO 80260 USA Natl Jewish Med & Res Ctr, Dept Med, Denver, CO 80260 USA Natl Jewish Med & Res Ctr Denver CO USA 80260 t Med, Denver, CO 80260 USA Natl Jewish Med & Res Ctr, Div Basic Sci, Denver, CO 80260 USA Natl JewishMed & Res Ctr Denver CO USA 80260 c Sci, Denver, CO 80260 USA Natl Jewish Ctr Immunol & Resp Med, Howard Hughes Med Inst, Denver, CO 80206 USA Natl Jewish Ctr Immunol & Resp Med Denver CO USA 80206 nver, CO 80206 USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
fascicolo: 4, volume: 21, anno: 1999,
pagine: 480 - 489
SICI:
1044-1549(199910)21:4<480:DOEAIA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-DEFICIENT MICE; PASSIVE TRANSFER; IGE PRODUCTION; MURINE MODEL; SERUM IGE; T-CELLS; ASTHMA; RESPONSIVENESS; MOUSE; HYPERREACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Gelfand, EW Natl Jewish Med & Res Ctr, Dept Pediat, 1400 Jackson St, Denver, CO 80260 USA Natl Jewish Med & Res Ctr 1400 Jackson St Denver CO USA 80260
Citazione:
E. Hamelmann et al., "Development of eosinophilic airway inflammation and airway hyperresponsiveness requires interleutkin-5 but not immunoglobulin E or B lymphocytes", AM J RESP C, 21(4), 1999, pp. 480-489

Abstract

We previously defined a role for B cells and allergen-specific immunoglobulins in the development of allergic sensitization, airway inflammation, andairway hyperresponsiveness (AHR), using a 10-d protocol in which allergen exposure occurred exclusively via the airways, without adjuvant. In the present protocol, normal and B-cell-deficient (mu Mt(-/-)) mice were sensitized intraperitoneally to ovalbumin (OVA) and challenged with OVA via the airways in order to examine the requirements for AHR with this protocol. T-cellactivation (antigen-specific proliferative responses and Th2-type cytokineproduction) and eosinophil infiltration in the peribronchial regions of the airways, with signs of eosinophil activation and degranulation, occurred in both experimental groups. In contrast to the 10-d protocol, increased invivo airway responsiveness to methacholine and in vitro tracheal smooth-muscle responses to electrical field stimulation were observed in both normaland B-cell-deficient mice, and these responses were inhibited by anti-interleukin (IL)-5 administration before airway challenge. These data show thatIL-5, but not B cells or allergen-specific IgE, are required for eosinophil airway infiltration and the development of AHR following allergen/alum sensitization and repeated airway challenge with allergen. These results emphasize that the use of different sensitization and challenge protocols can influence the requirements for development of AHR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 18:34:36