Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Surfactant protein-B-deficient mice are susceptible to hyperoxic lung injury
Autore:
Tokieda, K; Iwamoto, HS; Bachurski, C; Wert, SE; Hull, WM; Ikeda, K; Whitsett, JA;
Indirizzi:
Childrens Hosp, Med Ctr, Div Neonatol & Pulm Biol, Cincinnati, OH 45229 USA Childrens Hosp Cincinnati OH USA 45229 ulm Biol, Cincinnati, OH 45229 USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
fascicolo: 4, volume: 21, anno: 1999,
pagine: 463 - 472
SICI:
1044-1549(199910)21:4<463:SPMAST>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXYGEN-EXPOSED RATS; EXOGENOUS SURFACTANT; ALVEOLAR EPITHELIUM; GENE-EXPRESSION; MESSENGER-RNA; PHORBOL ESTER; SP-A; MOUSE; HOMEOSTASIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Whitsett, JA Childrens Hosp, Med Ctr, Div Neonatol & Pulm Biol, 3333 Burnet Ave, Cincinnati, OH 45229 USA Childrens Hosp 3333 Burnet Ave Cincinnati OH USA 45229 29 USA
Citazione:
K. Tokieda et al., "Surfactant protein-B-deficient mice are susceptible to hyperoxic lung injury", AM J RESP C, 21(4), 1999, pp. 463-472

Abstract

Surfactant protein-B (SP-B) is a small, hydrophobic peptide that plays a critical role in pulmonary function and surfactant homeostasis. To determinewhether SP-B protects mice from oxygen-induced injury, heterozygous SP-B+/- gene-targeted mice and wild-type SP-B+/+ littermates were exposed to hyperoxia (95% oxygen for 3 d) or room air. Although specific lung compliance in room air in SP-B+/- mice was slightly reduced as compared with that in SP-B+/+ mice, it was reduced more markedly during hyperoxia (46% versus 25% decrease, respectively). The larger decrease in lung compliance in SP-B+/- mice was associated with increased severity of pulmonary edema, hemorrhage and inflammation, lung permeability and protein leakage into the alveolar space. Hyperoxia increased SP-B messenger RNA (mRNA) and total protein concentrations by 2-fold in SP-B+/+ and SP-B+/- mice, but decreased the abundanceof SP-B protein in lavage fluid relative to total protein only in SP-B+/- mice. Hyperoxia increased SP-B expression, but apparently not enough to maintain SP-B function and lung compliance in the presence of increased protein leakage in SP-B+/- mice. Increased alveolar-capillary leakage and relative deficiency of SP-B may therefore contribute to oxygen-induced pulmonary dysfunction in SP-B+/- mice. These data support the concept that SP-B plays an important protective role in the lung.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 23:10:11