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Titolo:
Analysis of genomic alterations in sporadic adrenocortical lesions - Gain of chromosome 17 is an early event in adrenocortical tumorigenesis
Autore:
Zhao, JM; Speel, EJM; Muletta-Feurer, S; Rutimann, K; Saremaslani, P; Roth, J; Heitz, PU; Komminoth, P;
Indirizzi:
Univ Zurich, Dept Pathol, CH-8091 Zurich, Switzerland Univ Zurich ZurichSwitzerland CH-8091 thol, CH-8091 Zurich, Switzerland Univ Zurich, Div Cell & Mol Pathol, CH-8091 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8091 thol, CH-8091 Zurich, Switzerland
Titolo Testata:
AMERICAN JOURNAL OF PATHOLOGY
fascicolo: 4, volume: 155, anno: 1999,
pagine: 1039 - 1045
SICI:
0002-9440(199910)155:4<1039:AOGAIS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETIC ABERRATIONS; HUMAN SARCOMAS; TUMORS; HYBRIDIZATION; CARCINOMA; MALIGNANCY; MARKERS; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Komminoth, P Univ Zurich, Dept Pathol, Schmelzbergstr 12, CH-8091 Zurich, Switzerland Univ Zurich Schmelzbergstr 12 Zurich Switzerland CH-8091 and
Citazione:
J.M. Zhao et al., "Analysis of genomic alterations in sporadic adrenocortical lesions - Gain of chromosome 17 is an early event in adrenocortical tumorigenesis", AM J PATH, 155(4), 1999, pp. 1039-1045

Abstract

Genetic changes underlying the tumorigenesis of sporadic adrenocortical tumors are poorly characterized. To search for characteristic genomic imbalances involved in adrenocortical tumors, we examined 41 adrenocortical lesions (12 carcinomas, 23 adenomas, and 6 hyperplasias) by comparative genomic hybridization, Our results show that genetic alterations are more frequent in malignant than in benign lesions and that they rarely occur in hyperplastic lesions. The most frequent DNA copy number changes in adrenocortical carcinomas included losses of 1p21-31, 2q, 3p, 3q, 6q, 9p, and 11q14-qter, as well as gains and. amplifications of 5q12, 9q32-qter, 12q, and 20q. The genomic aberrations prevalently occurring in adrenocortical adenomas were gains of 17q, 17p, and 9q32-qter. Gains found in 2 of 6 adrenocortical hyperplastic lesions involved chromosome 17 or 17q only. These data indicate that oncogenes determining the early tumorigenesis of adrenocortical tumors may exist on chromosome 17 and that the number of genomic alterations is closelyassociated with tumor behavior in adrenocortical tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:49:43