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Titolo:
Comparison of a rapid field immunochromatographic test to expert microscopy for the detection of Plasmodium falciparum asexual parasitemia in Thailand
Autore:
Wongsrichanalai, C; Chuanak, N; Tulyayon, S; Thanoosingha, N; Laoboonchai, A; Thimasarn, K; Brewer, TG; Heppner, DG;
Indirizzi:
Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, ThailandArmed Forces Res Inst Med Sci Bangkok Thailand 10400 kok 10400, Thailand Minist Publ Hlth, Malaria Div, Dept Communicable Dis Control, Nonthaburi, Thailand Minist Publ Hlth Nonthaburi Thailand Dis Control, Nonthaburi, Thailand
Titolo Testata:
ACTA TROPICA
fascicolo: 3, volume: 73, anno: 1999,
pagine: 263 - 273
SICI:
0001-706X(19991015)73:3<263:COARFI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE-CHAIN-REACTION; ANTIGEN-CAPTURE ASSAY; PARASIGHT(TM)-F TEST; ANTIMALARIAL-DRUGS; MALARIA DIAGNOSIS; TREATMENT FAILURE; DIPSTICK TEST; INFECTION; PREDICT; PLASMA;
Keywords:
diagnosis; giemsa stain; P. falciparum histidine rich protein 2 (PfHRP2); ICT malaria Pf Test (TM) (ICT test); light microscopy; malaria rapid diagnostic device (MRDD); Plasmodium falciparum (Pf); Thailand;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Wongsrichanalai, C Armed Forces Res Inst Med Sci, Dept Immunol & Med, 315-6 Rajvithi Rd, Bangkok 10400, Thailand Armed Forces Res Inst Med Sci 315-6 Rajvithi Rd Bangkok Thailand 10400
Citazione:
C. Wongsrichanalai et al., "Comparison of a rapid field immunochromatographic test to expert microscopy for the detection of Plasmodium falciparum asexual parasitemia in Thailand", ACT TROP, 73(3), 1999, pp. 263-273

Abstract

We assessed a rapid, Plasmodium falciparum histidine rich protein 2 (PfHRP2)-based immunochromatographic test (ICT Malaria Pf Test(TM)), for detection of asexual P. falciparum parasitemia in 551 subjects in three groups: (1)symptomatic patients self-referring for diagnosis, (2) villagers in a screening survey, and (3) patients recently treated for P. falciparum malaria. Expert light microscopy was the reference standard. ICT test performance was similar for diagnostic and screening modes. Four findings emerged: (1) test sensitivity correlated directly with parasite density, (2) test band intensity correlated directly with parasite density, (3) persistent test positivity after parasite clearance precludes its use for monitoring early therapeutic responses, and (4) a false negative test at 18000 parasites/mu l is unexplained. We conclude that a strong positive ICT test is highly predictive of falciparum asexual parasitemia for the diagnosis of new cases of falciparum malaria in Thailand, but a negative test result is inadequate to exclude parasitemia < 300/mu l, and in some instances, even a higher parasitemia. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:42:55