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Titolo:
Vernal keratoconjunctivitis in a Stockholm ophthalmic centre - epidemiological, functional, and immunologic investigations
Autore:
Montan, PG; Ekstrom, K; Hedlin, G; van Hage-Hamsten, M; Hjern, A; Herrmann, B;
Indirizzi:
St Eriks Hosp, Dept Ophthalmol, S-11282 Stockholm, Sweden St Eriks Hosp Stockholm Sweden S-11282 halmol, S-11282 Stockholm, Sweden Huddinge Univ Hosp, Dept Pediat, Stockholm, Sweden Huddinge Univ Hosp Stockholm Sweden osp, Dept Pediat, Stockholm, Sweden Karolinska Hosp, Dept Clin Immunol, S-10401 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-10401 unol, S-10401 Stockholm, Sweden Swedish Natl Board Hlth & Welf, Epidemiol Ctr, Stockholm, Sweden Swedish Natl Board Hlth & Welf Stockholm Sweden Ctr, Stockholm, Sweden Huddinge Univ Hosp, Dept Clin Sci, Pediat Unit, Stockholm, Sweden HuddingeUniv Hosp Stockholm Sweden Sci, Pediat Unit, Stockholm, Sweden Univ Uppsala Hosp, Dept Clin Microbiol, Uppsala, Sweden Univ Uppsala HospUppsala Sweden , Dept Clin Microbiol, Uppsala, Sweden
Titolo Testata:
ACTA OPHTHALMOLOGICA SCANDINAVICA
fascicolo: 5, volume: 77, anno: 1999,
pagine: 559 - 563
SICI:
1395-3907(199910)77:5<559:VKIASO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
EOSINOPHIL CATIONIC PROTEIN; IMMUNOGLOBULIN-E ANTIBODIES; ALLERGIC-RHINITIS; SKIN-TESTS; CONJUNCTIVITIS; SERUM; IGE; CHILDREN; ASTHMA; TEARS;
Keywords:
vernal keratoconjunctivitis; epidemiology; atopy; chlamydia; bronchial hyperreactivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Montan, PG St Eriks Hosp, Dept Ophthalmol, Polhemsgatan 50, S-11282 Stockholm, Sweden St Eriks Hosp Polhemsgatan 50 Stockholm Sweden S-11282 Sweden
Citazione:
P.G. Montan et al., "Vernal keratoconjunctivitis in a Stockholm ophthalmic centre - epidemiological, functional, and immunologic investigations", ACT OPHTH S, 77(5), 1999, pp. 559-563

Abstract

Purpose: To classify a cohort of 62 patients with vernal keratoconjunctivitis (VKC) in immunologic, functional, and epidemiological terms. Methods: A retrospective chart review was conducted to establish the patients' ethnic origin and to ascertain the results of standard in vitro and invivo testing for atopic allergy. The latter data were compared with tear Phadiatop(R), an allergy screening test, in 31 subjects. Further subgroup analyses included methacholine bronchial provocations, serum screening for chlamydial antibodies and epidemiological calculations of the observed prevalence of VKC in the Stockholm area in 1994. Results: Thirty-seven subjects (59.7%) were sensitised to common allergens. No additional allergic subjects were diagnosed with the tear Phadiatop(R)test. The serology for ocular chlamydial disease was negative. Only 6 out of 17 subjects displayed bronchial reactivity to methacholine of whom 4 hada history of asthma, VKC was clearly more common in individuals with an Asian and African origin. Conclusions: Sensitivity to allergens is a strong determinant for the disease but in a large proportion of the subjects this immunologic abnormality is absent. The varying prevalence of the condition in different ethnic groups indicates a genetic predisposing factor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/10/20 alle ore 00:38:38