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Titolo:
Comparing the effects of four different perfluorocarbons on gas exchange and lung mechanics in an animal model of acute lung injury
Autore:
Hartog, A; Kaisers, U; Gommers, D; Lachmann, B;
Indirizzi:
Erasmus Univ, Dept Anesthesiol, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands Humboldt Univ, Charite Clin, Dept Anaesthesiol & Intens Care Med, Berlin, Germany Humboldt Univ Berlin Germany thesiol & Intens Care Med, Berlin, Germany
Titolo Testata:
ACP-APPLIED CARDIOPULMONARY PATHOPHYSIOLOGY
fascicolo: 1, volume: 8, anno: 1999,
pagine: 41 - 46
SICI:
0920-5268(1999)8:1<41:CTEOFD>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARTIAL LIQUID VENTILATION; RESPIRATORY-DISTRESS SYNDROME; DOSE-DEPENDENT IMPROVEMENT; FAILURE; FC-3280;
Keywords:
perfluorocarbons; artificial ventilation; lung injury; animal model; pulmonary surfactants;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Lachmann, B Erasmus Univ, Dept Anesthesiol, Room Ee2393,Post Box 1738, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Room Ee2393,Post Box 1738 Rotterdam Netherlands NL-3000 DR
Citazione:
A. Hartog et al., "Comparing the effects of four different perfluorocarbons on gas exchange and lung mechanics in an animal model of acute lung injury", APPL CARD P, 8(1), 1999, pp. 41-46

Abstract

Partial liquid ventilation (PLV), a hybrid technique that superimposes gasventilation on lungs that are filled with perfluorocarbons (PFCs), has been shown to improve oxygenation in animal models of acute lung injury (ALI). Several physico-chemical properties of perfluorocarbons are considered important in their capability to improve pulmonary function. This study was performed to allow a direct comparison of four perfluorocarbons with different physico-chemical properties during PLV with respect to gas exchange, lungmechanics, alveolar protein influx and surfactant system. Thirty-six adultmale Sprague-Dawley rats were anesthetized, tracheotomized and submitted to pressure controlled mechanical ventilation at an FiO(2) of 1.0, 30 breaths/min, I/E of 1:2, a positive inspiratory pressure (PIP) of 26 cmH(2)O, anda PEEP of 6 cmH(2)O. Acute lung injury was induced by repeated lung lavages to obtain a PaO2 < 100 mmHg. After steady state, animals were randomly divided teach group n=6) to receive either APF-140, APF-215, APF-175A or FC 3280 intratracheally, in a dose of 15 ml/kg body weight. One group received no PFCs, but was ventilated with a PIP of 28 cmH(2)O and a PEEP of 8 cmH(2)O (ventilated control group). Gas exchange was determined hourly during a 4h observation period. In the groups that received PFCs, evaporational losses were compensated for. Instillation of APF 175A resulted in a significantand sustained improvement in gas exchange, an increase in total lung capacity, and prevented an increase in alveolar protein influx. Instillation of APF 140 transiently increased oxygenation and prevented an increase in alveolar protein influx, but did not increase total lung capacity. In the othertwo perfluorocarbon treated groups, gas exchange did not improve and no differences were found compared with the ventilated controls. We conclude that the efficacy of perfluorocarbons to improve pulmonary function cannot be predicted based on their physico-chemical properties.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:15:22