Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Participation of the liver in generation of a vigorous anti-donor responseafter inoculation of donor spleen cells
Autore:
He, L; Gotoh, M; Dono, K; Nagano, H; Ota, H; Ohta, Y; Okuyama, M; Takeda, Y; Shimizu, J; Grochowiecki, T; Sakon, M; Monden, M;
Indirizzi:
Osaka Univ, Sch Med, Dept Surg 2, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Surg 2, Suita, Osaka 5650871, Japan Osaka Univ, Sch Med, Bioregulat Biomed Res Ctr, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Res Ctr, Suita, Osaka 5650871, Japan
Titolo Testata:
TRANSPLANTATION
fascicolo: 7, volume: 68, anno: 1999,
pagine: 950 - 957
SICI:
0041-1337(19991015)68:7<950:POTLIG>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PORTAL VENOUS INOCULATION; CARDIAC ALLOGRAFT SURVIVAL; INTRAPORTAL INJECTION; ALLOGENEIC CELLS; RATS; INDUCTION; DRAINAGE; TRANSPLANTATION; LYMPHOCYTES; TOLERANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Monden, M Osaka Univ, Sch Med, Dept Surg 2, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 650871, Japan
Citazione:
L. He et al., "Participation of the liver in generation of a vigorous anti-donor responseafter inoculation of donor spleen cells", TRANSPLANT, 68(7), 1999, pp. 950-957

Abstract

Background. There is a general agreement that a preferential accumulation of alloantigens within the Liver could induce hyporesponsiveness to the inoculated antigens. Entrapment of antigens in the Liver may evoke an unique immune response in the organ and play a key role in determination of the fate of the transplanted grafts. To understand the immune response in the liver after inoculation of allogeneic donor antigens, we examined the immune response to systemically inoculated alloantigen in rats whose sensitized liver was replaced with that of naive rats or in naive rats whose liver was replaced with that of sensitized rats. Methods. Using implantation of syngeneic liver (alloantigen-accumulated/naive) in rats (naive/alloantigen-sensitized), we compared the immune responses to alloantigen between rats with hepatic/extrahepatic alloantigen at 24 hr after alloantigen inoculation. This was called sensitized-liver-grafted (SLG)/sensitized-liver-removed (SLR) treatment. The immune response to donor alloantigen in this model was evaluated by survival of skin or heart grafts, complement-dependent cytotoxicity (CDC) titer and delayed-type hypersensitivity (DTH) response. Results. Compared with the mean survival time (MST) in donor spleen cell inoculated (DSI) rats (skin and heart, MST: 8.2+/-1.1 and 10.7+/-2.3 days), SLG rats rejected allografts in an accelerated fashion (skin and heart, MST: 5.5+/-0.5 and 4.2+/-0.8 days), associated with higher CDC titer and DTH response. In contrast, allograft survival was moderately prolonged in SLR (skin and heart, MST: 16.5+/-2.6 and 29.5+/-3.7 days)associated with suppressed CDC titer and DTH response. The survival of third-party allograft after SLG or SLR treatment (skin, MST: 9.3+/-1.5 or 9.7+/-0.6 days) indicated that immunological hyper/hyporesponsiveness was donor-specific. Conclusions. A strong anti donor immune response was induced by the transfer of donor antigen-baring Liver to naive rats 24 hr after alloantigen inoculation, whereas removal of the liver suppressed alloimmune response. Our results indicate that vigorous anti-alloimmune response occurred in the liver after systemic inoculation of donor spleen cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 21:04:19