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Titolo:
Regulation of methionine adenosyltransferase activity by the glutathione level in rat liver during ischemia-reperfusion
Autore:
Ito, K; Miwa, N; Hagiwara, K; Yano, T; Shimizu-Saito, K; Goseki, N; Iwai, T; Horikawa, S;
Indirizzi:
Tsuchiura Kyodo Hosp, Dept Surg, Tsuchiura, Ibaraki 3000053, Japan Tsuchiura Kyodo Hosp Tsuchiura Ibaraki Japan 3000053 araki 3000053, Japan
Titolo Testata:
SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY
fascicolo: 10, volume: 29, anno: 1999,
pagine: 1053 - 1058
SICI:
0941-1291(1999)29:10<1053:ROMAAB>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
S-ADENOSYLMETHIONINE SYNTHETASE; HEPATIC ISCHEMIA; FREE-RADICALS; INJURY; MODULATION;
Keywords:
methionine adenosyltransferase; oxidative stress; ischemia-reperfusion; liver;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Horikawa, S Tokyo Med & Dent Univ, Med Res Inst, Dept Pathol Biochem, Chiyoda Ku, 2-3-10 Kanda Surugadai, Tokyo 1010062, Japan Tokyo Med & Dent Univ 2-3-10 Kanda Surugadai Tokyo Japan 1010062
Citazione:
K. Ito et al., "Regulation of methionine adenosyltransferase activity by the glutathione level in rat liver during ischemia-reperfusion", SURG TODAY, 29(10), 1999, pp. 1053-1058

Abstract

Hepatic ischemia was induced by clamping the hepatic artery, portal vein, and bile duct, After 15 min of ischemia, the hepatic glutathione (GSH) content rapidly decreased. On the other hand, after the start of reperfusion, the hepatic GSH levels promptly increased and reached a peak at about 1 h, and thereafter decreased to a minimum level by 2 h. Under such conditions, we examined the changes in the methionine adenosyltransferase (MAT) activityin the liver. Though the time course of MAT activity was somewhat delayed compared with that of the hepatic GSH levels, both patterns were substantially similar during ischemia-reperfusion, In contrast to the changes in the MAT activity during ischemia-reperfusion, the levels of MAT protein were unchanged during these periods, When endogenous antioxidant coenzyme Q(10) (CoQ(10)) was administered to rats prior to ischemia, both the reduction in the MAT activity and hepatic GSH levels induced by ischemia-reperfusion wereprotected. Our findings suggest that CoQ(10) may post-translationally regulate the MAT activity via the changes in the GSH level in the liver.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:53:10