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Titolo:
Parallels between wound repair and morphogenesis in the embryo
Autore:
Grose, R; Martin, P;
Indirizzi:
Univ London Univ Coll, Dept Anat & Dev Biol, London WC1E 6BT, England UnivLondon Univ Coll London England WC1E 6BT , London WC1E 6BT, England
Titolo Testata:
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
fascicolo: 4, volume: 10, anno: 1999,
pagine: 395 - 404
SICI:
1084-9521(199908)10:4<395:PBWRAM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-SHAPE CHANGES; ACTIN STRESS FIBERS; GROWTH-FACTOR-BETA; DORSAL CLOSURE; MOUSE EMBRYO; MEDIATES MORPHOGENESIS; ELECTRON-MICROSCOPY; TERMINAL KINASE; C-ELEGANS; DROSOPHILA;
Keywords:
actin purse-string; embryo; morphogenesis; signalling; wound healing;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Grose, R ETH Honggerberg, Inst Cell Biol, HPM D42, CH-8093 Zurich, Switzerland ETH Honggerberg HPM D42 Zurich Switzerland CH-8093 , Switzerland
Citazione:
R. Grose e P. Martin, "Parallels between wound repair and morphogenesis in the embryo", SEM CELL D, 10(4), 1999, pp. 395-404

Abstract

The natural tissue movements of morphogenesis and the artificially-inducedmovements of tissue repair in the embryo bear remarkably close comparison. Both are largely driven by cell shape changes that in turn are powered by spatially regulated contractions of the actin cytoskeleton. Critical for assembly of these contractile actin machineries are the Rho family of small GTPase molecular switches which have now been shown to play a key role in regulating several morphogenetic movements as well as the epithelial component of embryonic wound healing. In this review we discuss further similarities between wound repair and morphogenesis, in particular focussing on cues that may initiate these processes and stop them when they are finished.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 02:45:34