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Titolo:
A PET study of D-1-like dopamine receptor ligand binding during altered endogenous dopamine levels in the primate brain
Autore:
Chou, YH; Karlsson, P; Halldin, C; Olsson, H; Farde, L;
Indirizzi:
Karolinska Hosp, Psychiat Sect, Dept Clin Neurosci, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 osci, S-17176 Stockholm, Sweden
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 146, anno: 1999,
pagine: 220 - 227
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; C-11 RACLOPRIDE BINDING; SCHIZOPHRENIC-PATIENTS; SYNAPTIC DOPAMINE; MOLECULAR-BIOLOGY; PREFRONTAL CORTEX; D1 RECEPTORS; STRIATUM; D-1; LOCALIZATION;
Keywords:
endogenous dopamine; positron emission tomography; D-1 dopamine receptor; reserpine; amphetamine; [C-11]NNC 112;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Chou, YH Karolinska Hosp, Psychiat Sect, Dept Clin Neurosci, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 7176 Stockholm, Sweden
Citazione:
Y.H. Chou et al., "A PET study of D-1-like dopamine receptor ligand binding during altered endogenous dopamine levels in the primate brain", PSYCHOPHAR, 146(2), 1999, pp. 220-227

Abstract

Rationale: Several positron emission tomography (PET) studies have shown that radioligand binding to D-2-like dopamine receptors competes with endogenous dopamine. Objective: The purpose of this PET study was to examine the effect of amphetamine and reserpine on D-1-like dopamine receptor binding. Methods: Three Cynomolgus monkeys were examined with the radioligands [C-11]SCH 23390 or [C-11]NNC 112 at baseline condition and after pretreatment with amphetamine (2 mg/kg IV). The B/F values (binding potential) in the striatum and the neocortex were calculated at transient equilibrium. In two monkeys, the effect of the long-lasting dopamine depletion after reserpine (1 mg/kg IV) was followed by a repeated Scatchard procedure in up to 77 days after drug administration. The Scatchard analysis was based on two PET measurements with high and low specific radioactivity and allowed the calculation of D-1-like dopamine receptor density (B-max) and apparent affinity (K-D(app)). Results: The effect of amphetamine on the B/F values was between -14and 6%. These changes can be considered as within the range of the test-retest reliability. Thus, there was no evident effect of amphetamine-induced dopamine release on D-1-like dopamine receptor binding. Five hours after reserpine administration, there was no change in B-max or K-D(app). At 3, 23,and 28 days after reserpine administration, the Scatchard analyses indicated a 13-20% reduction in B-max without any evident change in K-D(app) in both the striatum and the neocortex. Conclusions: The lack of evident effectsof amphetamine and reserpine on D-1-like dopamine receptor binding is markedly different from the 20% amphetamine-induced decrease and 50% reserpine-induced increase that has been consistently reported for D-1-like dopamine receptor binding. The data indicated that D-1-like dopamine receptor occupancy of endogenous dopamine is low at physiological condition. It is thus unlikely that D-1-like dopamine receptor radioligands can be used to measure changes in the concentration of endogenous dopamine.

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Documento generato il 26/01/20 alle ore 16:16:27