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Titolo:
CONTRIBUTION OF TNF TNF RECEPTOR AND OF FAS LIGAND TO TOXICITY IN MURINE MODELS OF ENDOTOXEMIA AND BACTERIAL PERITONITIS/
Autore:
HEUMANN D; LEROY D; ZANETTI G; EUGSTER HP; RYFFEL B; HAHNE M; TSCHOPP J; GLAUSER MP;
Indirizzi:
CHU VAUDOIS,DEPT INTERNAL MED,DIV INFECT DIS CH-1011 LAUSANNE SWITZERLAND SWISS FED INST TECHNOL,INST TOXICOL SCHWERZENBACH SWITZERLAND UNIV BASEL,DEPT PATHOL BASEL SWITZERLAND UNIV LAUSANNE,INST BIOCHEM CH-1066 EPALINGES SWITZERLAND
Titolo Testata:
Journal of inflammation
fascicolo: 4, volume: 47, anno: 1996,
pagine: 173 - 179
SICI:
1078-7852(1996)47:4<173:COTTRA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; FACTOR TNF RECEPTOR; MONOCLONAL-ANTIBODY; SEPTIC SHOCK; FACTOR-ALPHA; HEPATOCYTE APOPTOSIS; BABOON MODEL; CELL-DEATH; IN-VIVO; EFFICACY;
Keywords:
LPS; SEPTIC SHOCK; APOPTOSIS; PERITONITIS; BACTERIAL INFECTIONS; GALACTOSAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
D. Heumann et al., "CONTRIBUTION OF TNF TNF RECEPTOR AND OF FAS LIGAND TO TOXICITY IN MURINE MODELS OF ENDOTOXEMIA AND BACTERIAL PERITONITIS/", Journal of inflammation, 47(4), 1996, pp. 173-179

Abstract

Fas/Fas ligand and TNF/TNF receptors are involved in apoptosis. Whether both systems are involved in septic shock has not been determined so far We investigated the role of TNF/TNFR and Fas/Fas ligand in models of endotoxemia and of septicemia in mice. Upon LPS challenge TNF andTNFR p55 were involved in the process inducing lethality. Fast did not contribute to enhance lethality, as evidenced in gld mice, lacking FasL. Following an intraperitoneal injection of live E. coli, TNF and TNFR p55 were necessary to combat infection. Disruption of either gene was associated with enhanced lethality and failure to clear the bacteria. No effect was observed in gld mice in this peritonitis model. Thus, these observations confirmed the pathogenic role of TNF/TNFR in endotoxemia and its beneficial role in local bacterial infections. In addition the delta ruled out a major role for Fas/FasL in septic shock in mice. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 02:52:12