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Titolo:
Molecular and cellular biology of prostate cancer - the role of apoptosis as a target for therapy
Autore:
Costa-Pereira, AP; Cotter, TG;
Indirizzi:
Univ Coll, Dept Biochem, Tumour Biol Lab, Dublin, Ireland Univ Coll Dublin Ireland Dept Biochem, Tumour Biol Lab, Dublin, Ireland
Titolo Testata:
PROSTATE CANCER AND PROSTATIC DISEASES
fascicolo: 3, volume: 2, anno: 1999,
pagine: 126 - 139
SICI:
1365-7852(199905)2:3<126:MACBOP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; TUMOR-SUPPRESSOR GENE; IN-SITU HYBRIDIZATION; COMPARATIVE GENOMIC HYBRIDIZATION; P53 PROTEIN ACCUMULATION; ANDROGEN-RECEPTOR GENE; FAS-MEDIATED APOPTOSIS; E-CADHERIN EXPRESSION; CARCINOMA-CELLS; METASTASIS-SUPPRESSOR;
Keywords:
prostate cancer; review; oncogenes; humour suppressor genes; growth factors; apoptosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
198
Recensione:
Indirizzi per estratti:
Indirizzo: Cotter, TG Univ Coll, Dept Biochem, Tumour Biol Lab, Dublin, Ireland Univ Coll Dublin Ireland m, Tumour Biol Lab, Dublin, Ireland
Citazione:
A.P. Costa-Pereira e T.G. Cotter, "Molecular and cellular biology of prostate cancer - the role of apoptosis as a target for therapy", PROSTATE C, 2(3), 1999, pp. 126-139

Abstract

Despite the high incidence and mortality rate of prostate cancer, the molecular mechanisms underlying the progression of the disease remain to be fully elucidated. This paper reviews the current state of knowledge on prostatic carcinogenesis, focusing not only on the molecular genetics of prostate cancer, but also on the role of oncogenes, tumour suppressor genes, and growth factors. The remarkable ability of prostate cancer cells to survive androgen withdrawal and apoptosis are discussed, with particular emphasis on how apoptosis may be manipulated from a therapeutic viewpoint.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/21 alle ore 16:23:55