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Titolo:
Localization and changes in superoxide dismutase immunoreactivity in rat pulp after tooth preparation
Autore:
Baumgardner, KR; Law, AS; Gebhart, GE;
Indirizzi:
Univ Michigan, Sch Dent, Dept Cardiol Restorat Sci & Endodont, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 & Endodont, Ann Arbor, MI 48109 USA Univ Iowa, Dept Pharmacol, Iowa City, IA 52242 USA Univ Iowa Iowa City IAUSA 52242 Dept Pharmacol, Iowa City, IA 52242 USA
Titolo Testata:
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS
fascicolo: 4, volume: 88, anno: 1999,
pagine: 488 - 495
SICI:
1079-2104(199910)88:4<488:LACISD>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR NECROSIS FACTOR; NITRIC-OXIDE; FREE-RADICALS; DENTAL-PULP; MANGANESE; INFLAMMATION; PHAGOCYTES; DIFFERENTIATION; EXPRESSION; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Baumgardner, KR Univ Michigan, Sch Dent, Dept Cardiol Restorat Sci & Endodont, 1011 N UnivSt, Ann Arbor, MI 48109 USA Univ Michigan 1011 N Univ St Ann Arbor MI USA 48109 09 USA
Citazione:
K.R. Baumgardner et al., "Localization and changes in superoxide dismutase immunoreactivity in rat pulp after tooth preparation", ORAL SURG O, 88(4), 1999, pp. 488-495

Abstract

Objective. To examine the distribution of superoxide in the uninflamed andinflamed dental pulp by characterizing the immunoreactivity of the detoxifying antioxidant enzymes, manganese and copper-zinc superoxide dismutases (MnSOD and CuZnSOD, respectively). Study design. In 12 rats, mesial cavity preparations were made on the maxillary right first molar; left molars were unoperated controls. After 5 days, the rats were killed, and histologic sections were processed by using MnSOD and CuZnSOD immunoreactivity, and the extent of inflammation was evaluated on alternate sections stained with hematoxylin and eosin. Results. In the hematoxylin and eosin-stained sections, inflammation was consistent with : macrophages, lymphocytes, and plasma cells that coalesced into a distinct leukocytic "lesion," which obliterated portions of the underlying pulp. Both MnSOD and CuZnSOD immunoreactivity increased dramaticallyin inflammatory cells within the leukocytic lesion and in the tissue surrounding the lesion. Conclusions. The findings suggest that the protective role of SOD increases within pulp cells that are undergoing inflammatory stimulation. SOD immunoreactivity may be an early indicator of stress in pulp.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/08/20 alle ore 19:44:26