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Titolo:
c-Myb is critical for murine colon development
Autore:
Zorbas, M; Sicurella, C; Bertoncello, I; Venter, D; Ellis, S; Mucenski, ML; Ramsay, RG;
Indirizzi:
Peter MacCallum Canc Inst, Melbourne, Vic 8006, Australia Peter MacCallum Canc Inst Melbourne Vic Australia 8006 ic 8006, Australia Childrens Hosp, Med Ctr, Div Pulm Biol, Cincinnati, OH 45229 USA ChildrensHosp Cincinnati OH USA 45229 ulm Biol, Cincinnati, OH 45229 USA
Titolo Testata:
ONCOGENE
fascicolo: 42, volume: 18, anno: 1999,
pagine: 5821 - 5830
SICI:
0950-9232(19991014)18:42<5821:CICFMC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
BCL-2 EXPRESSION; FORCED EXPRESSION; DOWN-REGULATION; CELL-DEATH; GASTROINTESTINAL-TRACT; INTESTINAL EPITHELIUM; POLYCYSTIC KIDNEY; MICE LACKING; BETA-CATENIN; APOPTOSIS;
Keywords:
c-Myb; epithelium; gut; gene knockout; apoptosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Ramsay, RG Peter MacCallum Canc Inst, Locked Bag 1,Abeckett St, Melbourne,Vic 8006, Australia Peter MacCallum Canc Inst Locked Bag 1,Abeckett St Melbourne Vic Australia 8006
Citazione:
M. Zorbas et al., "c-Myb is critical for murine colon development", ONCOGENE, 18(42), 1999, pp. 5821-5830

Abstract

The mammalian colon develops from a simple tube of undifferentiated cells into a complex, highly ordered organ,,vith a continuously self-renewing epithelial layer, We have previously described c-Myb expression in the epithelia of murine and human colon crypts and documented increased expression in colorectal adenocarcinoma cells. To investigate the role of c-Myb in colonic epithelium development, we have used embryos with a disrupted c-myb gene,Prior to the in utero death of these embryos at E15, we excised colon tissue and transplanted it under the kidney capsule of recipient mice to allow further development and cyto-differentiation. Compared to the colons of wildtype and heterozygous littermates, the c-myb homozygous knockout colon is highly irregular with a disordered epithelium and abnormal crypts, In addition, the expression of Bcl-2, a known target of c-Myb, is reduced and apoptosis is increased, indicating a critical requirement for c-Myb in normal colon development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 20:09:31