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Titolo:
The T102C polymorphism of the 5-HT2A-receptor gene in fibromyalgia
Autore:
Bondy, B; Spaeth, M; Offenbaecher, M; Glatzeder, K; Stratz, T; Schwarz, M; de Jonge, S; Kruger, M; Engel, RR; Farber, L; Pongratz, DE; Ackenheil, M;
Indirizzi:
Univ Munich, Hosp Psychiat, D-80336 Munich, Germany Univ Munich Munich Germany D-80336 osp Psychiat, D-80336 Munich, Germany Univ Munich, Dept Phys Med & Rehabil, D-80336 Munich, Germany Univ MunichMunich Germany D-80336 ed & Rehabil, D-80336 Munich, Germany Hochrhein Inst, Clin Rheumatol, D-79713 Bad Sackingen, Germany Hochrhein Inst Bad Sackingen Germany D-79713 9713 Bad Sackingen, Germany Novartis Pharma GMBH, D-90429 Nurnberg, Germany Novartis Pharma GMBH Nurnberg Germany D-90429 D-90429 Nurnberg, Germany
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 5, volume: 6, anno: 1999,
pagine: 433 - 439
SICI:
0969-9961(199910)6:5<433:TTPOT5>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR AFFECTIVE-DISORDER; CHRONIC-FATIGUE-SYNDROME; 5HT(2A) RECEPTOR GENE; 5-HT2A RECEPTOR; CHRONIC PAIN; ASSOCIATION; SEROTONIN; SCHIZOPHRENIA; CLASSIFICATION; MANAGEMENT;
Keywords:
fibromyalgia; serotonin; 5-HT2A-receptors; polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Bondy, B Univ Munich, Hosp Psychiat, Nussbaumstr 7, D-80336 Munich, Germany Univ Munich Nussbaumstr 7 Munich Germany D-80336 Munich, Germany
Citazione:
B. Bondy et al., "The T102C polymorphism of the 5-HT2A-receptor gene in fibromyalgia", NEUROBIOL D, 6(5), 1999, pp. 433-439

Abstract

Based on a possible involvement of serotonergic dysfunction in the pathophysiology of fibromyalgia (FM) and on preliminary reports of a possible genetically driven vulnerability for this disorder we investigated the silent T102C polymorphism of the 5-HT2A-receptor gene in 168 FM patients and 115 healthy controls. Our results showed a significantly different genotype distribution in FM patients with a decrease in T/T and an increase in both T/C and C/C genotypes as compared to the control population (Fisher's Exact test, two-sided, P = 0.008). However, the increase in allele-C102 frequency felt short of significance (P = 0.07). Correlation of genotypes to clinical parameters revealed no influences on age of onset, duration of disease or psychopathological symptoms, measured with the Beck Depression Inventory and the symptom checklist SCL-90-R. In contrast to that the pain score, being a self reported information on pain severity, was significantly higher in patients of the T/T genotype (Mann-Whitney U test, P = 0.028). This suggests that the T102-allele might be involved in the complex circuits of nociception. However, the T102C polymorphism is not directly involved in the aetiology of FM but might be in linkage dysequilibrium with the true functional variant, which has to be unravelled. (C) 1999 Academic Press.

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Documento generato il 28/09/20 alle ore 10:41:34