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Titolo:
Haem oxygenase-1 prevents cell death by regulating cellular iron
Autore:
Ferris, CD; Jaffrey, SR; Sawa, A; Takahashi, M; Brady, SD; Barrow, RK; Tysoe, SA; Wolosker, H; Baranano, DE; Dore, S; Poss, KD; Snyder, SH;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 urosci, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Med, Div Gastroenterol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 nterol, Baltimore, MD 21205 USA Skidmore Coll, Dept Chem & Phys, Saratoga Springs, NY 12866 USA Skidmore Coll Saratoga Springs NY USA 12866 aratoga Springs, NY 12866 USA MIT, Dept Biol, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139MIT, Dept Biol, Cambridge, MA 02139 USA Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205USA Johns Hopkins Univ Baltimore MD USA 21205 Mol Sci, Baltimore, MD 21205USA Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 av Sci, Baltimore, MD 21205 USA
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 3, volume: 1, anno: 1999,
pagine: 152 - 157
SICI:
1465-7392(199907)1:3<152:HOPCDB>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEME OXYGENASE; CARBON-MONOXIDE; PROTEIN; APOPTOSIS; STRESS; IDENTIFICATION; FIBROBLASTS; EXPRESSION; REDUCTASE; NECROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Ferris, CD Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205USA Johns Hopkins Univ Baltimore MD USA 21205 timore, MD 21205 USA
Citazione:
C.D. Ferris et al., "Haem oxygenase-1 prevents cell death by regulating cellular iron", NAT CELL BI, 1(3), 1999, pp. 152-157

Abstract

Haem oxygenase-1 (HO1) is a heat-shock protein that is induced by stressful stimuli. Here we demonstrate a cytoprotective role for HO1: cell death produced by serum deprivation, staurosporine or etoposide is markedly accentuated in cells from mice with a targeted deletion of the HO1 gene, and greatly reduced in cells that overexpress HO1. Iron efflux from cells is augmented by HO1 transfection and reduced in HO1-deficient fibroblasts, Iron accumulation in HO1-deficient cells explains their death: iron chelators protectHO1-deficient fibroblasts from cell death. Thus, cytoprotection by HO1 is attributable to its augmentation of iron efflux, reflecting a role for HO1 in modulating intracellular iron levels and regulating cell viability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 23:59:26