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Titolo:
The trophoblastic epithelial barrier is not infected in full-term placentae of human immunodeficiency virus-seropositive mothers undergoing antiretroviral therapy
Autore:
Tscherning-Casper, C; Papadogiannakis, N; Anvret, M; Stolpe, L; Lindgren, S; Bohlin, AB; Albert, J; Fenyo, EM;
Indirizzi:
Karolinska Inst, Microbiol & Tumorbiol Ctr, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 Ctr, S-17177 Stockholm, Sweden Karolinska Inst, Huddinge Hosp, Dept Pathol, S-10401 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-10401 thol, S-10401 Stockholm, Sweden Karolinska Inst, Huddinge Hosp, Dept Obstet & Gynecol, S-10401 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-10401 ecol, S-10401 Stockholm, Sweden Karolinska Inst, Huddinge Hosp, Dept Pediat, S-10401 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-10401 diat, S-10401 Stockholm, Sweden Karolinska Hosp, Dept Clin Genet, S-10401 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-10401 enet, S-10401 Stockholm, Sweden Karolinska Hosp, Dept Clin Neurosci, S-10401 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-10401 osci, S-10401 Stockholm, Sweden Swedish Inst Infect Dis Control, Stockholm, Sweden Swedish Inst Infect DisControl Stockholm Sweden rol, Stockholm, Sweden
Titolo Testata:
JOURNAL OF VIROLOGY
fascicolo: 11, volume: 73, anno: 1999,
pagine: 9673 - 9678
SICI:
0022-538X(199911)73:11<9673:TTEBIN>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; HIV TYPE-1 VARIANTS; FETAL TRANSMISSION; DNA AMPLIFICATION; CELLS; LOCALIZATION; WOMEN; REPLICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Fenyo, EM Karolinska Inst, Microbiol & Tumorbiol Ctr, Box 280, S-17177 Stockholm, Sweden Karolinska Inst Box 280 Stockholm Sweden S-17177 ckholm, Sweden
Citazione:
C. Tscherning-Casper et al., "The trophoblastic epithelial barrier is not infected in full-term placentae of human immunodeficiency virus-seropositive mothers undergoing antiretroviral therapy", J VIROLOGY, 73(11), 1999, pp. 9673-9678

Abstract

To study the mechanism of the placental barrier function, we examined 10 matched samples of term placentae, cord blood, and maternal blood obtained at delivery from human immunodeficiency virus (HN)infected mothers with children diagnosed as HIV negative in Sweden. All placentae were histologicallynormal, and immunochemistry for HIV type 1 p24 and gp120 antigens was negative. Highly purified trophoblasts (93 to 99% purity) were negative for HIVDNA and RNA, indicating that the trophoblasts were uninfected. Although HIV DNA was detected in placenta-derived T lymphocytes and monocytes, microsatellite analysis showed that these cells were a mixture of maternal and fetal cells. Our study indicates that the placental barrier, i.e., the trophoblastic layer, is not HIV infected and, consequently, HIV infection of the fetus is likely to occur through other routes, such as breaks in the placental barrier.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/08/20 alle ore 04:59:01