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Titolo:
The lysosomal enzymes acid phosphatase and cathepsin D in rats intoxicatedwith Senna occidentalis seeds
Autore:
Calore, EE; Calore, NMP; Weg, R; Cavaliere, MJ; Da Rosa, AR; Dias, SD;
Indirizzi:
Emilio Ribas Inst, Pathol Sect, BR-01246902 Sao Paulo, Brazil Emilio RibasInst Sao Paulo Brazil BR-01246902 BC46902 Sao Paulo, Brazil Univ Sao Paulo, Sch Vet Med, Dept Pathol, Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil Vet Med, Dept Pathol, Sao Paulo, Brazil Adolfo Lutz Inst, Div Pathol, Sao Paulo, Brazil Adolfo Lutz Inst Sao Paulo Brazil z Inst, Div Pathol, Sao Paulo, Brazil
Titolo Testata:
JOURNAL OF SUBMICROSCOPIC CYTOLOGY AND PATHOLOGY
fascicolo: 2, volume: 31, anno: 1999,
pagine: 259 - 264
SICI:
1122-9497(199904)31:2<259:TLEAPA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL-MUSCLE; MITOCHONDRIAL MYOPATHY; DENERVATION; GROWTH;
Keywords:
lysosome; Senna occidentalis; toxic plants; toxic myopathies; mitochondria;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Calore, EE Emilio Ribas Inst, Pathol Sect, Av Dr Arnaldo 165, BR-01246902 Sao Paulo, Brazil Emilio Ribas Inst Av Dr Arnaldo 165 Sao Paulo Brazil BR-01246902 BC
Citazione:
E.E. Calore et al., "The lysosomal enzymes acid phosphatase and cathepsin D in rats intoxicatedwith Senna occidentalis seeds", J SUBMIC CY, 31(2), 1999, pp. 259-264

Abstract

Chronic administration of Senna occidentalis seeds induces an experimentaltoxic myopathy characterized by skeletal muscle fibers atrophy, decrease in histochemical activity of cytochrome oxidase, and increase of the acid phosphatase activity in muscle fibres at the light microscopic level. The mechanisms that lead to the increase of this lysosomal enzyme activity are notknown and could be related to other biochemical disturbs than the mitochondrial function impairment. The main aim of the present: study is to localize the acid phosphatase activity using a cytochemical method at transmissionelectron microscopy level and to quantify cathepsin D in muscle of rats chronically intoxicated with Senna occidentalis seeds by immunoblotting. Acidphosphatase was observed in lysosomes and over profiles of some organellesapparently not involved by lysosomal membrane. In addition immunoblotting demonstrated a decrease in the content of the precursor and of the mature form of cathepsin D in samples of muscles and liver of intoxicated animals. We concluded that there is a selective increase in acid phosphatase activity in muscle - and maybe in other tissues - of animals intoxicated with Senna occidentalis, that can be related to the skeletal muscle atrophy and the intense decrease in weight gain of these animals. Further studies should beperformed to establish the mechanisms of selectivity in increase of lysosomal enzymes in different situations and pathological stares.

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Documento generato il 19/02/20 alle ore 14:59:32