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Titolo:
Neurotoxic basolateral amygdala lesions impair learning and memory but notthe performance of conditional fear in rats
Autore:
Maren, S;
Indirizzi:
Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ept Psychol, Ann Arbor, MI 48109 USA Univ Michigan, Neurosci Program, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 sci Program, Ann Arbor, MI 48109 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 19, volume: 19, anno: 1999,
pagine: 8696 - 8703
SICI:
0270-6474(19991001)19:19<8696:NBALIL>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTENTIATED STARTLE; SYNAPTIC TRANSMISSION; PERIAQUEDUCTAL GRAY; EXCITOTOXIC LESIONS; TEMPORAL GRADIENT; NMDA RECEPTORS; ACQUISITION; EXPRESSION; RESPONSES; PLASTICITY;
Keywords:
amygdala; NMDA; lesion; overtraining; learning; memory; conditioning; freezing; fear;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Maren, S Univ Michigan, Dept Psychol, 525 E Univ Ave, Ann Arbor, MI 48109 USA Univ Michigan 525 E Univ Ave Ann Arbor MI USA 48109 MI 48109 USA
Citazione:
S. Maren, "Neurotoxic basolateral amygdala lesions impair learning and memory but notthe performance of conditional fear in rats", J NEUROSC, 19(19), 1999, pp. 8696-8703

Abstract

We examined the influence of extensive overtraining (75 trials) on the impact of neurotoxic basolateral amygdala (BLA) lesions on Pavlovian fear conditioning in rats. As we have shown previously, pretraining BLA lesions yielded severe deficits in the acquisition of conditional freezing in rats trained with either 1 or 25 conditioning trials. However, extensive overtraining (50 or 75 trials) mitigated deficits in conditional freezing. Under theseconditions the rats with BLA lesions expressed normal and robust freezing behavior, although they required at least 10 times as much training as control rats to reach this level of performance. The ability of rats with BLA lesions to acquire and express conditional freezing after extensive overtraining was modality-specific; conditional freezing in individual rats was acquired to contextual, but not acoustic, conditional stimuli. These results suggest that neural circuitry outside of the amygdala can mediate contextualfear conditioning under some conditions. In contrast to pretraining lesions, post-training BLA lesions eradicated the memory for Pavlovian fear in rats trained with either 1 or 75 trials; this deficit was not modality-specific. Together, these results reveal that impairments in the acquisition and expression of conditional fear in rats with BLA lesions are not attributable to deficits in the performance of the freezing response but are attributable to disruptions in the learning and memory of Pavlovian fear conditioning.

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Documento generato il 23/09/20 alle ore 13:08:16