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Titolo:
Ovariectomy of adult rats leads to increased expression of astrocytic basic fibroblast growth factor in the ventral tegmental area and in dopaminergic projection regions of the entorhinal and prefrontal cortex
Autore:
Flores, C; Salmaso, N; Cain, S; Rodaros, D; Stewart, J;
Indirizzi:
Concordia Univ, Dept Psychol, Ctr Studies Behav Neurobiol, Montreal, PQ H3G 1M8, Canada Concordia Univ Montreal PQ Canada H3G 1M8 l, Montreal, PQ H3G 1M8, Canada
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 19, volume: 19, anno: 1999,
pagine: 8665 - 8673
SICI:
0270-6474(19991001)19:19<8665:OOARLT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENDRITIC SPINE DENSITY; MESSENGER-RNA EXPRESSION; INDUCED LOCOMOTOR-ACTIVITY; FIBRILLARY ACIDIC PROTEIN; CORTICAL PYRAMIDAL CELLS; CENTRAL-NERVOUS-SYSTEM; ESTROGEN-RECEPTOR; BASAL FOREBRAIN; GLIAL-CELLS; TYROSINE-HYDROXYLASE;
Keywords:
estrogen; astrocytes; bFGF; ventral tegmental area; entorhinal cortex; prefrontal cortex; dendritic arbor; Golgi; GFAP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Stewart, J Concordia Univ, Dept Psychol, Ctr Studies Behav Neurobiol, 1455Maisonneuve Blvd, Montreal, PQ H3G 1M8, Canada Concordia Univ 1455 Maisonneuve Blvd Montreal PQ Canada H3G 1M8
Citazione:
C. Flores et al., "Ovariectomy of adult rats leads to increased expression of astrocytic basic fibroblast growth factor in the ventral tegmental area and in dopaminergic projection regions of the entorhinal and prefrontal cortex", J NEUROSC, 19(19), 1999, pp. 8665-8673

Abstract

Changes in astrocytic function may underlie the neurochemical and morphological alterations in limbic and cortical areas after estrogen loss in adultfemales. We assessed whether increased expression of basic fibroblast growth factor (bFGF), an astrocytic response involved in injury-induced neuronal plasticity, occurs after ovariectomy. We examined bFGF immunoreactivity (IR) in ovariectomized rats with oil or estradiol benzoate (5 mu g every 4 d; Experiment 1) and in ovariectomized and intact animals (Experiment 2). Inthe ventral tegmental area (VTA), bFGF-IR and glial fibrillary acidic protein (GFAP)-IR were greater in ovariectomized animals than in animals with estrogen replacement. bFGF-IR in the VTA was greater in ovariectomized than in intact females. In the dorsal raphe, no differences between groups were found in GFAP-IR or bFGF-IR. In mesolimbic dopaminergic target areas withinentorhinal cortex (Ent), prefrontal cortex, and nucleus accumbens, bFGF-IRwas higher in Ent of ovariectomized animals 4 weeks after surgery in both experiments, but no differences were seen in nucleus accumbens or in an occipital cortical, control, area in either study. In Experiment 2, small increases in bFGF-IR were seen in the prefrontal cortex after ovariectomy. In the VTA and Ent, changes in bFGF-IR developed gradually, peaking at 4 weeks and waning at 40 weeks. Furthermore, increased dendritic arbor of Ent layerII/III pyramidal cells was found in ovariectomized females with the use ofa modified Golgi-Cox staining procedure. These findings suggest that, within specific regions, ovariectomy induces astrocytic responses similar to those observed after injury that may affect neuronal chemistry and morphology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:32:13