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Titolo:
C/EBP regulates the promoter of the eosinophil-derived neurotoxin/RNS2 gene in human eosinophilic cells
Autore:
Baltus, B; Buitenhuis, M; van Dijk, TB; Vinson, C; Raaijmakers, JAM; Lammers, JWJ; Koenderman, L; de Groot, RP;
Indirizzi:
Univ Utrecht Hosp, Dept Pulm Dis, NL-3584 CX Utrecht, Netherlands Univ Utrecht Hosp Utrecht Netherlands NL-3584 CX CX Utrecht, Netherlands NCI, Biochem Lab, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892NCI, Biochem Lab, NIH, Bethesda, MD 20892 USA
Titolo Testata:
JOURNAL OF LEUKOCYTE BIOLOGY
fascicolo: 4, volume: 66, anno: 1999,
pagine: 683 - 688
SICI:
0741-5400(199910)66:4<683:CRTPOT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING-PROTEIN-ALPHA; FACTOR-RECEPTOR PROMOTER; PULMONARY IMMUNE CELLS; TRANSCRIPTION FACTOR; CATIONIC PROTEIN; MOLECULAR-CLONING; LINEAGE COMMITMENT; INTRONIC ENHANCER; FAMILY MEMBERS; DEFICIENT MICE;
Keywords:
granulocytes; transcription regulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: de Groot, RP Univ Utrecht Hosp, Dept Pulm Dis, G03-550,Heidelberglaan 100,NL-3584 CX Utrecht, Netherlands Univ Utrecht Hosp G03-550,Heidelberglaan 100 Utrecht Netherlands NL-3584 CX
Citazione:
B. Baltus et al., "C/EBP regulates the promoter of the eosinophil-derived neurotoxin/RNS2 gene in human eosinophilic cells", J LEUK BIOL, 66(4), 1999, pp. 683-688

Abstract

The eosinophil-derived neurotoxin (EDN), a member of the mammalian ribonuclease family, is found in the large specific granules of human eosinophilicleukocytes. We have investigated the role of the C/EBP transcription factor family in the regulation of EDN promoter activity. Here we show that the C/EBP family is involved in intrinsic regulation of EDN promoter activity. We have identified a C/EBP binding site located at -124 in the proximal promoter of the EDN gene. Mutation of this C/EBP site results in a decrease ofpromoter activity in HL-60-eos cells as well as in eosinophils differentiated in vitro from CD34(+) cells. Different C/EBP proteins are able to bind to the C/EBP site as shown by gel shift assay. Our results indicate the importance of the C/EBP family in the regulation of the EDN gene in eosinophils.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:34:43