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Titolo:
Immunohistochemical analysis of vascular prostheses implanted with the left ventricular assist system
Autore:
Fastenau, DR; Labarrere, CA; Hormuth, DA; McIntyre, JA;
Indirizzi:
Methodist Hosp Indiana, Ctr Reprod & Transplantat Immunol, Indianapolis, IN 46202 USA Methodist Hosp Indiana Indianapolis IN USA 46202 dianapolis, IN 46202 USA
Titolo Testata:
JOURNAL OF HEART AND LUNG TRANSPLANTATION
fascicolo: 9, volume: 18, anno: 1999,
pagine: 916 - 920
SICI:
1053-2498(199909)18:9<916:IAOVPI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTIFICIAL CIRCULATION; BIOLOGICAL SEALANTS; KNITTED DACRON; ARTERIAL GRAFT; IN-VITRO; COLLAGEN; THROMBOGENICITY; ACTIVATION; POROSITY; FIBRIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: McIntyre, JA Methodist Hosp Indiana, Ctr Reprod & Transplantat Immunol, 1701 N Senate Blvd, Indianapolis, IN 46202 USA Methodist Hosp Indiana 1701 N Senate Blvd Indianapolis IN USA 46202
Citazione:
D.R. Fastenau et al., "Immunohistochemical analysis of vascular prostheses implanted with the left ventricular assist system", J HEART LUN, 18(9), 1999, pp. 916-920

Abstract

Background: Dacron vascular pros-theses are associated with thromboemboliccomplications and inflammatory responses; impregnation with bovine collagen reportedly stimulates additional inflammatory/immunologic complications. The Novacor (Baxter Healthcare Corp., Oakland, CA, USA) left ventricular assist system uses Dacron inflow and collagen-impregnated Dacron outflow prostheses. Methods: Explanted inflow and outflow prostheses were evaluated for inflammatory/immunologic, hemostatic, anticoagulant, and fibrinolytic pathways. Non-implanted prostheses immersed in whole blood or plasma were used as controls. Results: Immunoglobulins and complement components were observed in all prostheses with activated macrophages being present only in implanted prostheses; Antithrombin III was observed in all prostheses whereas fibrin, tissueplasminogen activator, and alpha-2 plasmin inhibitor were present only in implanted prostheses. Endothelial and smooth muscle cells associated with Vascular structures containing collagen type IV and laminin were observed solely in implanted prostheses. Conclusion: An inflammatory response occurs and key components of hemostatic, anticoagulant, and fibrinolytic pathways are present within implanted prostheses. These processes are accompanied by endothelial and smooth musclecell infiltration which appear to lay the foundation for neovessel development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 16:21:27