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Titolo:
Advances in enamel remineralization: Casein phosphopeptide-amorphous calcium phosphate
Autore:
Reynolds, EC; Black, CL; Cai, F; Cross, KJ; Eakins, D; Huq, NL; Morgan, MV; Nowicki, A; Perich, JW; Riley, PF; Shen, P; Talbo, G; Webber, F;
Indirizzi:
Univ Melbourne, Sch Dent Sci, Melbourne, Vic 3000, Australia Univ Melbourne Melbourne Vic Australia 3000 elbourne, Vic 3000, Australia
Titolo Testata:
JOURNAL OF CLINICAL DENTISTRY
fascicolo: 2, volume: 10, anno: 1999,
pagine: 86 - 88
SICI:
0895-8831(1999)10:2<86:AIERCP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SODIUM CASEINATE; CARIES; RAT; CARIOGENICITY; CHEESE; PLAQUE; MILK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Reynolds, EC Univ Melbourne, Sch Dent Sci, Melbourne, Vic 3000, Australia Univ Melbourne Melbourne Vic Australia 3000 3000, Australia
Citazione:
E.C. Reynolds et al., "Advances in enamel remineralization: Casein phosphopeptide-amorphous calcium phosphate", J CLIN DENT, 10(2), 1999, pp. 86-88

Abstract

Casein phosphopeptides (CPP) are multi-phosphorylated peptides from an enzymatic digest of the bovine milk protein casein. These peptides have a remarkable ability to stabilize calcium phosphate in solution as amorphous calcium phosphate (ACP). Through their multiple phosphoseryl residues, the CPP bind to forming nanoclusters of ACP in metastable solution, preventing their growth to the critical size required for nucleation and phase transformations. The casein phosphopeptide-amorphous calcium phosphate (CPP-ACP: Recaldent(TM)) nano clusters have been shown to localize at the tooth surface and prevent caries in laboratory, animal and human in situ caries models. TheCPP-ACP have also been shown to remineralize enamel subsurface lesions in vitro and in situ when delivered in a sugar-free chewing gum. The proposed anticariogenic mechanism for CPP-ACP is the localization of ACP at the tooth surface which buffers the free calcium and phosphate ion activities, thereby helping to maintain a state of supersaturation with respect to tooth enamel, depressing demineralization and enhancing remineralization. The CPP-ACP have potential as an additive to foods and oral care products for the control of dental caries.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:08:55