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Titolo:
BIOLOGICAL CHARACTERISTICS OF AN ENZOOTIC SUBTYPE OF WESTERN EQUINE ENCEPHALOMYELITIS VIRUS FROM ARGENTINA
Autore:
BIANCHI TI; AVILES G; SABATTINI MS;
Indirizzi:
INST NACL ENFERMEDADES VIRALES HUAMNAS DR JI MAIZ,MONTEAGUDO 2510 RA-2700 PERGAMINO ARGENTINA RELAC INT,SERV NACL SANIDAD ANIM BUENOS AIRES DF ARGENTINA INST VIROL DR JM VANELLA CORDOBA ARGENTINA
Titolo Testata:
Acta virologica
fascicolo: 1, volume: 41, anno: 1997,
pagine: 13 - 20
SICI:
0001-723X(1997)41:1<13:BCOAES>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARBOVIRUS INVESTIGATIONS; AEDES-ALBIFASCIATUS; MOSQUITOS DIPTERA; ENCEPHALITIS; CULICIDAE; ISOLATIONS; COMPLEX;
Keywords:
WESTERN EQUINE ENCEPHALOMYELITIS COMPLEX VIRUSES; BIOLOGICAL MARKERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
T.I. Bianchi et al., "BIOLOGICAL CHARACTERISTICS OF AN ENZOOTIC SUBTYPE OF WESTERN EQUINE ENCEPHALOMYELITIS VIRUS FROM ARGENTINA", Acta virologica, 41(1), 1997, pp. 13-20

Abstract

In order to expand our knowledge on the biological characteristics ofan enzootic South American subtype of western equine encephalomyelitis (WEE) virus, strain AG80-646, we inoculated guinea pigs, rabbits, newborn chickens and Vero and chick embryo cell cultures with this and other WEE and WEE-related viruses. AG80-646 was found apathogenic for guinea pigs even when inoculated intracranially (i.c.) or intraperitoneally (i.p.), and the animals did not develop viraemia. AG80-646 killedrabbits and the animals developed high viraemia (peak titer was 7.0 log PFU/0.1 ml). These data and previous serological evidence led us tolook for a mammal as a natural host. AG80-646 was found lethal for newborn chickens inoculated subcutaneously (s.c. ) (peak viraemia titer was 6.6 log PFU/0.1 ml). AG80-646 produced plaques (diameter 0.8 - 1.0 mm) in Vero and chick embryo cells 3-4 days post infection (p.i.). A comparison of AG80-646 with other WEE complex virus strains led to the following observations: (1) The lethality for guinea pigs was high forthe two epizootic Argentinian strains, Cba 87 and Cba CIV 180, zero for the two enzootic strains, AG80-646 and BeAr 10315 (virus Aura), andintermediate for the Russian strain Y62-33 (low by i.c. route and zero by i.p. route); (2) AG80-646 was more virulent for rabbits inoculated i.p. than the three epizootic strains Cba 87, Cba CIV 180 and McMillan; (3) AG80-646 was less virulent for new-born chickens than the Argentinian epizootic strain Cba CIV 180; (4) The viraemia level correlated always with the strain virulence in each animal host. This study provides tools for the differentiation of WEE complex viruses and strainsin the future ecological work on WEE in South America.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:05:38