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Titolo:
[H-3]Paroxetine binding to human peripheral lymphocyte membranes of patients with major depression before and after treatment with fluoxetine
Autore:
Urbina, M; Pineda, S; Pinango, L; Carreira, I; Lima, L;
Indirizzi:
Inst Venezolano Invest Cient, Ctr Biofis & Bioquim, Lab Neuroquim, Caracas1020A, Venezuela Inst Venezolano Invest Cient Caracas Venezuela 1020A cas1020A, Venezuela Ctr Salud Mental Este, Caracas, Venezuela Ctr Salud Mental Este Caracas Venezuela Mental Este, Caracas, Venezuela
Titolo Testata:
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY
fascicolo: 10, volume: 21, anno: 1999,
pagine: 631 - 646
SICI:
0192-0561(199910)21:10<631:[BTHPL>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; BETA-ADRENERGIC RECEPTORS; SEROTONIN TRANSPORTER; UNIPOLAR DEPRESSION; IMMUNE-RESPONSE; T-CELLS; IMIPRAMINE BINDING; INTERFERON-GAMMA; PANIC DISORDER; H-3 PAROXETINE;
Keywords:
fluoxetine; lymphocytes; major depression; paroxetine; serotonin; serotonin carrier;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Lima, L Inst Venezolano Invest Cient, Ctr Biofis & Bioquim, Lab Neuroquim,Apdo 21827, Caracas 1020A, Venezuela Inst Venezolano Invest Cient Apdo 21827 Caracas Venezuela 1020A a
Citazione:
M. Urbina et al., "[H-3]Paroxetine binding to human peripheral lymphocyte membranes of patients with major depression before and after treatment with fluoxetine", INT J IMMUN, 21(10), 1999, pp. 631-646

Abstract

Serotonin has been involved in major depression and is also related to central and peripheral mechanisms of neuroimmunomodulation. Recently, the uptake of [H-3]serotonin into human peripheral blood lymphocytes has been reported. We determined the density of serotonin uptake sites by the binding of [H-3]paroxetine to blood peripheral lymphocyte membrane preparations of controls and of patients with major depression before and after treatment withfluoxetine for six weeks. The severity of depression was assessed by the use of Hamilton Rating Scale for Depression and of Beck Depression Inventory. There was a reduction in the number of sites for [H-3]paroxetine in patients before administration of the antidepressant respecting controls, and a recovery after the treatment. Affinity was unchanged. No correlation was obtained between the severity of symptoms determined by Hamilton Rating Scalefor Depression or by Beck Depression Inventory, and the number of binding sites for [H-3]paroxetine. The levels of the plasma serotonin metabolite, 5-hydroxyindoleacetic acid, did not differ between the three groups of subjects, but serotonin was lower in patients after treatment respecting controls and in patients before treatment. The significant correlation between specific binding of [H-3]paroxetine and plasma serotonin levels in controls was not present in the patients. Lymphocyte serotonin transporter is decreased in major depressed patients and is modulated by antidepressant treatment. In addition of counting with a peripheral marker in depression, the study of serotonin system in lymphocytes might contribute to understand the bi-directional interaction between the nervous and the immune systems. (C) 1999 International Society for Immunopharmacology. Published by Elsevier ScienceLtd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 22:39:36