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Titolo:
Effects of aztreonam on natural immunity in mice
Autore:
Ortega, E; de Pablo, MA; M, A; Gallego; Alvarez, C; Pancorbo, PL; Ruiz-Bravo, A; de Cienfuegos, GA;
Indirizzi:
Univ Jaen, Dept Hlth Sci, Jaen 23071, Spain Univ Jaen Jaen Spain 23071Univ Jaen, Dept Hlth Sci, Jaen 23071, Spain Univ Granada, Dept Microbiol, E-18071 Granada, Spain Univ Granada Granada Spain E-18071 ept Microbiol, E-18071 Granada, Spain
Titolo Testata:
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
fascicolo: 1, volume: 13, anno: 1999,
pagine: 41 - 46
SICI:
0924-8579(199909)13:1<41:EOAONI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN POLYMORPHONUCLEAR LEUKOCYTES; BETA-LACTAM ANTIBIOTICS; T-LYMPHOCYTE FUNCTION; IN-VITRO; STAPHYLOCOCCUS-AUREUS; HOST-DEFENSE; IMIPENEM; INVITRO; CHEMILUMINESCENCE; CIPROFLOXACIN;
Keywords:
beta-lactams; aztreonam; natural immunity; cytokines; chemiluminescence; natural killer activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: de Cienfuegos, GA Univ Jaen, Dept Hlth Sci, Paraje Las Lagunillas S-N, Jaen 23071, Spain Univ Jaen Paraje Las Lagunillas S-N Jaen Spain 23071 in
Citazione:
E. Ortega et al., "Effects of aztreonam on natural immunity in mice", INT J ANT A, 13(1), 1999, pp. 41-46

Abstract

The influence of the dose and the duration of treatment with aztreonam, a monocyclic p-lactam antibiotic, on the natural immune response of mice has been investigated. The results show the effects induced by the antibiotic on several immune parameters were affected by the duration of treatment. Thus, treatment with 28 mg/kg per day of aztreonam over 14 days increased every immune parameter tested, while treatment with 57 mg/kg per day of aztreonam for 7 days only enhanced the natural killer (NK) activity of splenocytes. Since aztreonam does not apparently impair the innate immune response, itmight be a suitable therapy for the treatment of patients who are immunosuppressed. (C) 1999 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 07:27:40