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Titolo:
Dimeric inhibins and activin A in human follicular fluid and oocyte-cumulus culture medium
Autore:
Lau, CP; Ledger, WL; Groome, NP; Barlow, DH; Muttukrishna, S;
Indirizzi:
Univ Oxford, John Radcliffe Hosp, Nuffield Dept Obstet & Gynaecol, Oxford OX3 9DU, England Univ Oxford Oxford England OX3 9DU t & Gynaecol, Oxford OX3 9DU, England Oxford Brookes Univ, Sch Biol & Mol Sci, Oxford OX3 0BP, England Oxford Brookes Univ Oxford England OX3 0BP Sci, Oxford OX3 0BP, England
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 10, volume: 14, anno: 1999,
pagine: 2525 - 2530
SICI:
0268-1161(199910)14:10<2525:DIAAAI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT GRANULOSA-CELLS; HUMAN MENSTRUAL-CYCLE; IN-VITRO; RECOMBINANT ACTIVIN; MEIOTIC MATURATION; SECRETION; FOLLISTATIN; RECEPTOR; INVITRO; EMBRYO;
Keywords:
activin A; follicular fluids; inhibin A; inhibin B; oocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Muttukrishna, S Univ Oxford, John Radcliffe Hosp, Nuffield Dept Obstet & Gynaecol, Oxford OX3 9DU, England Univ Oxford Oxford England OX3 9DU ford OX3 9DU, England
Citazione:
C.P. Lau et al., "Dimeric inhibins and activin A in human follicular fluid and oocyte-cumulus culture medium", HUM REPR, 14(10), 1999, pp. 2525-2530

Abstract

The concentrations of inhibin A, inhibin B and activin A in follicular fluid and oocyte culture medium were analysed to investigate the production ofthese peptide hormones by ovarian granulosa cells and oocyte-cumulus complexes, as well as their potential as possible biochemical markers for oocytequality and fertilizing capacity. Follicular fluids were collected from individual follicles during oocyte retrieval for in-vitro fertilization (IVF), Oocyte-cumulus culture media were collected after in-vitro insemination. The concentrations of dimeric inhibin A, inhibin B and activin A were measured using two-site enzyme-linked immunosorbent assays in the follicular fluid and matched oocyte culture medium, Hormone concentrations were compared with oocyte quality and fertilizing capacity. The concentration of inhibin A in follicular fluid increased while that of inhibin B decreased with increasing follicle size. Follicular fluid concentrations of inhibin A inhibin B and activin A were not significantly different in follicles with differing oocyte quality. Oocyte culture medium concentrations of activin A were significantly higher in morphologically good quality oocytes, There was no relationship between the concentrations of the three hormones and oocyte fertilizing capacity. This study confirms that follicular fluid concentrations of inhibin A may prove to be a marker of follicular growth and maturation. Higher concentrations of activin A produced by good quality oocyte-cumulus complexes suggest that activin A may play a role in oocyte maturation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 13:35:51