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Titolo:
Effects of estradiol and calcium on gonadotrophic cells in middle-aged female rats
Autore:
Lovren, M; Sekulic, M; Milosevic, V; Micic, M; Radulovic, N;
Indirizzi:
Inst Biol Res Sinisa Stankov, Dept Cytol, YU-11060 Belgrade, Yugoslavia Inst Biol Res Sinisa Stankov Belgrade Yugoslavia YU-11060 de, Yugoslavia Immunol Res Ctr Branislav Jankov, Belgrade, Yugoslavia Immunol Res Ctr Branislav Jankov Belgrade Yugoslavia lgrade, Yugoslavia
Titolo Testata:
HISTOCHEMICAL JOURNAL
fascicolo: 10, volume: 31, anno: 1999,
pagine: 671 - 676
SICI:
0018-2214(199910)31:10<671:EOEACO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLICLE-STIMULATING-HORMONE; LUTEINIZING-HORMONE; PITUITARY GONADOTROPE; INTRACELLULAR CALCIUM; SECRETION; ESTROGEN; LH; RELEASE; OVARIAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Lovren, M Inst Biol Res Sinisa Stankov, Dept Cytol, 29 Novembra 142, YU-11060 Belgrade, Yugoslavia Inst Biol Res Sinisa Stankov 29 Novembra 142 Belgrade Yugoslavia YU-11060
Citazione:
M. Lovren et al., "Effects of estradiol and calcium on gonadotrophic cells in middle-aged female rats", HISTOCHEM J, 31(10), 1999, pp. 671-676

Abstract

The effects of multiple treatment with estradiol dipropionate (EDP) or calcium glucoheptonate (Ca) or a combination of the two on gonadotrophic cellsin the pituitary pars distalis of middle-aged female rats were examined. The animals were treated daily for two weeks with EDP (0.625 mg i.p./kg bodyweight) or Ca (11.4 mg/kg body weight) or EDP+Ca. Luteinising (LH) and follicle stimulating hormone (FSH)-producing cells were examined by immunohistochemistry using antisera to the specific (beta) beta-subunits of LH and FSH and a peroxidase-anti-peroxidase immunohistochemical procedure. Plasma levels of FSH and LH were measured by radio-immune assay. A stereological method for determining morphometric parameters in immunopositive FSH and LH cells was used. The number of gonadotrophs per unit area (mm(2)), their cellular volume and relative volume densities, as well as plasma levels of FSH and LH, were decreased in all treated females in comparison with the controls. The most significant decrease of these parameters was observed in EDP-treated animals. Such changes were also expressed in Ca-treated animals, but the alterations were less distinct. These results demonstrate that multipleEDP or Ca application to middle-aged female rats is able to inhibit, directly or indirectly, the morphofunctional state of gonadotrophic cells in thepituitary pars distalis.

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Documento generato il 12/08/20 alle ore 20:31:34