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Titolo:
The relationship between allozyme and chromosomal polymorphism inferred from nucleotide variation at the Acph-1 gene region of Drosophila subobscura
Autore:
Navarro-Sabate, A; Aguade, M; Segarra, C;
Indirizzi:
Univ Barcelona, Fac Biol, Dept Genet, E-08071 Barcelona, Spain Univ Barcelona Barcelona Spain E-08071 t Genet, E-08071 Barcelona, Spain
Titolo Testata:
GENETICS
fascicolo: 2, volume: 153, anno: 1999,
pagine: 871 - 889
SICI:
0016-6731(199910)153:2<871:TRBAAC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLASE MULTIGENE FAMILY; MOLECULAR EVOLUTION; MITOCHONDRIAL-DNA; RP49 REGION; GEOGRAPHIC SUBDIVISION; INVERSION POLYMORPHISM; BACKGROUND SELECTION; NONNEUTRAL EVOLUTION; STATISTICAL TESTS; POPULATION-GROWTH;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Segarra, C Univ Barcelona, Fac Biol, Dept Genet, Diagonal 645, E-08071 Barcelona, Spain Univ Barcelona Diagonal 645 Barcelona Spain E-08071 ona, Spain
Citazione:
A. Navarro-Sabate et al., "The relationship between allozyme and chromosomal polymorphism inferred from nucleotide variation at the Acph-1 gene region of Drosophila subobscura", GENETICS, 153(2), 1999, pp. 871-889

Abstract

The Acph-1 gene region was sequenced in 51 lines of Drosophila subobscura. Lines differ in their chromosomal arrangement for segment I of the O chromosome (O-st and O3+4) and in the Acph-1 electrophoretic allele (Acph-1(100), Acph-1(054), and Acph-1(>100)). The ACPH-1 protein exhibits much more variation than previously detected by electrophoresis. The amino acid replacements responsible for the Acph-1(054) and Acph-1(>100) electrophoretic variants are different within O-st and within O3+4, which invalidates all previous studies on linkage disequilibrium between chromosomal and allozyme polymorphisms at this locus. The Acph-1(>100) allele within O3+4 has a recent origin, while both Acph-1(054) alleles are rather old. Levels of nucleotide variation are higher within the O3+4 than within the O-st arrangement exceptfor nonsynonymous sites. The McDonald and Kreitman test shows a significant excess of nonsynonymous polymorphisms within O-st when D. guanche is usedas the outgroup. According to the nearly neutral model of molecular evolution, this excess is consistent with a smaller effective size of O-st relative to O3+4 arrangements. A smaller population size, a lower recombination, and a more recent bottleneck might be contributing to the smaller effectivesize of O-st.

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Documento generato il 04/12/20 alle ore 13:09:07