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Titolo:
Effects of 50mg amisulpride on EEG, psychomotor and cognitive functions inhealthy sleep-deprived subjects
Autore:
Patat, A; Rosenzweig, P; Miget, N; Allain, H; Gandon, JM;
Indirizzi:
Biotrial SA, Drug Evaluat & Pharmacol Res, F-35000 Rennes, France BiotrialSA Rennes France F-35000 Pharmacol Res, F-35000 Rennes, France Synthelabo Rech, Dept Clin Pharmacol, F-92225 Bagneux, France Synthelabo Rech Bagneux France F-92225 harmacol, F-92225 Bagneux, France Univ Rennes Hosp, F-35043 Rennes, France Univ Rennes Hosp Rennes France F-35043 nnes Hosp, F-35043 Rennes, France
Titolo Testata:
FUNDAMENTAL & CLINICAL PHARMACOLOGY
fascicolo: 5, volume: 13, anno: 1999,
pagine: 582 - 594
SICI:
0767-3981(1999)13:5<582:EO5AOE>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR ANTAGONIST; ANTIPSYCHOTIC DRUG; LIMBIC SELECTIVITY; CAFFEINE; SCHIZOPHRENIA; NEUROLEPTICS; PERFORMANCE; DEPRIVATION; PSYCHOSTIMULANT; VOLUNTEERS;
Keywords:
sleep deprivation; amisulpride; EEG; cognitive functions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Patat, A Wyeth Lederle, Wyeth Ayerst Res, 80 Ave Charles Gaulle, F-92031 Paris, France Wyeth Lederle 80 Ave Charles Gaulle Paris France F-92031 France
Citazione:
A. Patat et al., "Effects of 50mg amisulpride on EEG, psychomotor and cognitive functions inhealthy sleep-deprived subjects", FUN CL PHAR, 13(5), 1999, pp. 582-594

Abstract

Amisulpride, a substituted benzamide, binds selectively to the dopamine D-2- and D-3-receptors. It has higher affinity for limbic compared to striatal dopamine receptors in vivo. At low doses, amisulpride facilitates dopamine transmission via a selective blockade of presynaptic D-2- and D-3-receptors. Amisulpride is an active antipsychotic compound effective at low doses for negative symptoms and at high doses for positive symptoms of schizophrenia. The CNS profile of multiple doses of a low dosage regimen of amisulpride (50 mg once daily for 4 days) was assessed in a randomised, double-blind, 3-way crossover, placebo-controlled study carried cut in 12 young sleep-deprived (for 36 h) subjects, using EEG and various measures of psychomotor and cognitive functions. Caffeine slow release (600 mg) was used as a positive reference. Multiple doses of 50 mg amisulpride once daily were devoid of any detrimental effects on EEG and psychomotor performance and cognitive function after total sleep deprivation. In addition, 50mg amisulpride partially antagonized the deleterious effects of sleep deprivation on EEG and subjective sedation as shown by trends, and a significant increase in EEG relative beta power and a decrease in subjective sedation. These effects were more pronounced at the end of sleep deprivation, suggesting possible alerting effects of amisulpride at this dose level. Caffeine significantly antagonized the detrimental effects of sleep deprivation on vigilance (increase in EEG beta waves, speed of reaction, sustained attention and reduction in subjective sedation). In conclusion, the present results demonstrate that 50mg amisulpride is devoid of detrimental effects on EEG, psychomotor and cognitive performance after sleep deprivation, a situation well-known to amplify such effects if they exist. Moreover, some data suggest possible alerting effects of this low dosage regimen of amisulpride. (C) 1999 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:31:14