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Titolo:
Myofibroblasts and S-100 protein positive cells in idiopathic pulmonary fibrosis and rheumatoid arthritis-associated interstitial pneumonia
Autore:
Yoshinouchi, T; Ohtsuki, Y; Ueda, R; Sato, S; Ueda, N;
Indirizzi:
Nagoya City Univ, Sch Med, Dept Internal Med 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 Nagoya, Aichi 4678601, Japan Gamagori City Hosp, Dept Internal Med, Gamagori, Japan Gamagori City HospGamagori Japan p, Dept Internal Med, Gamagori, Japan Kochi Med Sch, Dept Pathol 2, Nankoku, Kochi, Japan Kochi Med Sch NankokuKochi Japan , Dept Pathol 2, Nankoku, Kochi, Japan Ehime Prefectural Cent Hosp, Dept Internal Med, Matsuyama, Ehime, Japan Ehime Prefectural Cent Hosp Matsuyama Ehime Japan atsuyama, Ehime, Japan
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 3, volume: 14, anno: 1999,
pagine: 579 - 584
SICI:
0903-1936(199909)14:3<579:MASPPC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE ACTIN; GRANULATION-TISSUE; LUNG; FIBROBLASTS; GROWTH; ADENOCARCINOMAS; EXPRESSION; PROGNOSIS; FEATURES; SITES;
Keywords:
idiopathic pulmonary fibrosis; interstitial pneumonia; myofibroblast; rheumatoid arthritis; S-100 protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Yoshinouchi, T Nagoya City Univ, Sch Med, Dept Internal Med 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 4678601, Japan
Citazione:
T. Yoshinouchi et al., "Myofibroblasts and S-100 protein positive cells in idiopathic pulmonary fibrosis and rheumatoid arthritis-associated interstitial pneumonia", EUR RESP J, 14(3), 1999, pp. 579-584

Abstract

The aim of this study was to investigate whether idiopathic pulmonary fibrosis (IPF) can be distinguished from rheumatoid arthritis (RA)-associated interstitial pneumonia (RB-TP) by means of quantitatively assessing myofibroblasts and S-100 protein positive dendritic cells. Seven patients with IPF and twelve with RA, in whom the pathological findings were consistent with usual interstitial pneumonia (UIP) were studied. Antibodies to vimentin, alpha-smooth muscle actin (alpha-SMA) and S-100 protein were used for immunohistochemical studies performed using the streptavidin/biotin/peroxidase complex method, applied to dewaxed sections from eachcase. In fibrosis of RA-IP, appearance of both vimentin- and alpha-SMA-positive cells, namely myofibroblasts, was widely observed, together with the pathological patterns of honeycombing, UIP and bronchiolitis obliterans-organizing pneumonia (BOOP). Fibrosis, in cases of chronic IPF, was found to be characterized mainly by vimentin-positive but alpha-SMA-negative fibroblasts. Pulmonary tissues from RA-IP patients especially when associated with a BOOPpattern, contained many cells positive for S-100 protein. However, such cells were generally hard to find in cases of IPF. These findings suggests that idiopathic pulmonary fibrosis and rheumatoid arthritis-associated interstitial pneumonia can be differentiated from eachother, to some extent, based on the appearance of myofibroblasts and the presence of S-100-positive dendritic cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:50:30