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Titolo:
Reduced cerebrospinal HVA concentrations and HVA/5-HIAA ratios in suicide attempters - Monoamine metabolites in 120 suicide attempters and 47 controls
Autore:
Engstrom, G; Alling, C; Blennow, K; Regnell, G; Traskman-Bendz, L;
Indirizzi:
Malmo Univ Hosp, Dept Community Med, S-20502 Malmo, Sweden Malmo Univ Hosp Malmo Sweden S-20502 ommunity Med, S-20502 Malmo, Sweden Univ Lund Hosp, Dept Med Neurochem, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 t Med Neurochem, S-22185 Lund, Sweden Gothenburg Univ, Molndal Hosp, Inst Clin Neurosci, Dept Psychiat & Neurochem, S-43180 Molndal, Sweden Gothenburg Univ Molndal Sweden S-43180 eurochem, S-43180 Molndal, Sweden Univ Lund Hosp, Dept Clin Neurosci, Psychiat Sect, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 , Psychiat Sect, S-22185 Lund, Sweden
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 9, anno: 1999,
pagine: 399 - 405
SICI:
0924-977X(199909)9:5<399:RCHCAH>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CSF-AMINE METABOLITES; 5-HYDROXYINDOLEACETIC ACID; NEUROTRANSMITTER INTERACTIONS; DEPRESSED-PATIENTS; FLUID; BEHAVIOR; SCHIZOPHRENIA; DISORDERS; SEROTONIN; 5-HIAA;
Keywords:
monoamine metabolites; serotonin; dopamine; suicide; depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Engstrom, G Malmo Univ Hosp, Dept Community Med, S-20502 Malmo, Sweden Malmo Univ Hosp Malmo Sweden S-20502 , S-20502 Malmo, Sweden
Citazione:
G. Engstrom et al., "Reduced cerebrospinal HVA concentrations and HVA/5-HIAA ratios in suicide attempters - Monoamine metabolites in 120 suicide attempters and 47 controls", EUR NEUROPS, 9(5), 1999, pp. 399-405

Abstract

Dysfunctions of central monoaminergic systems are important elements of the leading biological hypotheses of suicide and depression. The purpose of the present paper was to study the levels and the relationships between the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), the dopamine metabolite homovanillic acid (HVA) and the norepinephrine metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) in the cerebrospinal fluid (CSF) in 120 hospitalised suicide attempters and 47 controls (healthy volunteers or patients admitted for minor surgery). The suicide attempters showed significantly lower HVA levels (174 +/- 82 vs. 216 +/- 96 nmol/L, P=0.004), HVA/5HIAA ratios(1.6 +/- 0.5 vs. 2.1 +/- 0.6, P=0.0001) and HVA/MHPG ratios (4.2 +/- 2.1 vs. 4.8 +/- 1.7, P=0.02) than the controls. The correlations between the monoamine metabolites were markedly lower in patients than in controls. CSF 5-HIAA showed no significant differences between patients and controls (107 +/- 40 vs. 108 +/- 51 nmol/L) or between violent and non-violent attempters (112 +/- 58 vs. 105 +/- 33 nmol/L). The monoamine metabolites showed no significant differences between survivors and patients who subsequently completed suicide, or between suicide attempters subgrouped by psychiatric diagnoses. The results suggest that low HVA levels and altered relationships between the monoamine metabolites are associated with suicidal behaviour. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 26/01/20 alle ore 01:14:45