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Titolo:
Mechanisms of action of selective serotonin reuptake inhibitors in the treatment of psychiatric disorders
Autore:
Nutt, DJ; Forshall, S; Bell, C; Rich, A; Sandford, J; Nash, J; Argyropoulos, S;
Indirizzi:
Univ Bristol, Sch Med Sci, Psychopharmacol Unit, Bristol BS8 1TD, Avon, England Univ Bristol Bristol Avon England BS8 1TD Bristol BS8 1TD, Avon, England
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
, volume: 9, anno: 1999, supplemento:, 3
pagine: S81 - S86
SICI:
0924-977X(199907)9:<S81:MOAOSS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; TRYPTOPHAN DEPLETION; PANIC DISORDER; RAPID DEPLETION; CITALOPRAM; FLUVOXAMINE; DEPRESSION; PAROXETINE; EFFICACY; PLACEBO;
Keywords:
selective serotonin reuptake inhibitors; depression; anxiety disorders; tryptophan depletion; serotonergic receptors; pharmacokinetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Nutt, DJ Univ Bristol, Sch Med Sci, Psychopharmacol Unit, Univ Walk, Bristol BS8 1TD, Avon, England Univ Bristol Univ Walk Bristol Avon England BS8 1TD Avon, England
Citazione:
D.J. Nutt et al., "Mechanisms of action of selective serotonin reuptake inhibitors in the treatment of psychiatric disorders", EUR NEUROPS, 9, 1999, pp. S81-S86

Abstract

Selective serotonin reuptake inhibitors (SSRIs) have demonstrated efficacyin depression and anxiety disorders. This raises the question of how the single action of serotonin reuptake inhibition can improve several psychiatric conditions. In order to understand this apparent paradox it is necessaryto consider where SSRIs act in the pathogenic process underlying depression or anxiety disorders. Tryptophan depletion has been used extensively in research into depression and has shown that, in patients receiving an SSRI whose depression is in remission, depleting serotonin leads to recurrence ofthe disorder. Similar results have been found for panic disorder. This suggests that increased levels of serotonin are necessary in the synapse for the SSRI to be effective in the treatment of depression and panic disorder. In obsessive compulsive disorder, depletion of serotonin in patients recovered on an SSRI does not cause relapse; receptor adaptation may be more important. Variations within the SSRI drug class, such as the selectivity ratios for serotonin versus noradrenaline uptake, elimination half-life, and affinity for the 5-HT2 receptor have been identified and may be important determinants of efficacy, side effects and clinical use. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 11:41:21