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Titolo:
Fat- and bone marrow-impregnated small diameter PTFE grafts
Autore:
Frechette, E; Dion, YM; Cardon, A; Chakfe, N; Doillon, CJ;
Indirizzi:
Univ Laval, Dept Surg, St Foy, PQ G1K 7P4, Canada Univ Laval St Foy PQ Canada G1K 7P4 Dept Surg, St Foy, PQ G1K 7P4, Canada
Titolo Testata:
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
fascicolo: 4, volume: 18, anno: 1999,
pagine: 308 - 314
SICI:
1078-5884(199910)18:4<308:FABMSD>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR GRAFTS; ENDOTHELIAL-CELLS; DACRON GRAFTS; POLYTETRAFLUOROETHYLENE GRAFTS; ARTERIAL RECONSTRUCTIONS; NEOINTIMAL HYPERPLASIA; ADIPOSE-TISSUE; IN-VITRO; PROSTHESES; FAILURE;
Keywords:
vascular prosthesis; small diameter vessel replacement; bone-marrow; PTFE; omental tissue; healing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Doillon, CJ Inst Biomat EO178, 10 Rue Espinay, Quebec City, PQ G1L 3L5, Canada Inst Biomat EO178 10 Rue Espinay Quebec City PQ Canada G1L 3L5
Citazione:
E. Frechette et al., "Fat- and bone marrow-impregnated small diameter PTFE grafts", EUR J VAS E, 18(4), 1999, pp. 308-314

Abstract

Objectives: to evaluate an alternative and simple technique which consistsin impregnation of a synthetic prosthesis with either autogenic omental fat or bone marrow. These tissues have been selected based on previous works and because they contain multiple cellular and extracellular compounds withbiological healing properties (i.e. angiogenesis, endothelialisation, etc.). Design: PTFE grafts of Group 1 were impregnated with fatty tissue, those of Group 2 with bone marrow and those of Group 3 served as controls. Materials: nine mongrel dogs divided among these three groups. PTFE graftsare 3 mm in diameter. Methods: in each animal, both iliac arteries were submitted to an end-to-side ilio-iliac bypass. At 3 months, pathology assessment was performed. Results: group 1: all grafts were thrombosed and intimal hyperplasia was found occluding the anastomotic sites. Group 2: 4/6 grafts were patent and their mid-portion presented a thin neointima which did not totally cover theanastomotic sites. Group 3: 2/5 grafts were patent and their mid-portion as well as the anastomotic sites were covered with neointima which tons hyperplastic in some areas. Conclusions: addition of bone marrow cells may contribute to improve the quality of the healing process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 03:14:33