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Titolo:
Pharmacokinetic determinants of cocaine's differential effects on locomotor and operant behavior
Autore:
Lau, CE; Wang, YM; Sun, L; Lobarinas, E; Wang, Q; Nguyen, KN; Falk, JL;
Indirizzi:
Rutgers State Univ, Dept Psychol, Piscataway, NJ 08854 USA Rutgers State Univ Piscataway NJ USA 08854 chol, Piscataway, NJ 08854 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 381, anno: 1999,
pagine: 85 - 92
SICI:
0014-2999(19990924)381:2-3<85:PDOCDE>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHEDULE-CONTROLLED BEHAVIOR; DISCRIMINATIVE MOTOR FUNCTIONS; RELATING DRL PERFORMANCE; CAFFEINE; ALPRAZOLAM; MONKEYS; RATS; STIMULATION; MIDAZOLAM; TOLERANCE;
Keywords:
fixed-ratio schedule; cocaine, intravenous; operant behavior; pharmacokinetics; pharmacodynamics; locomotor activity, spontaneous;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Lau, CE Rutgers State Univ, Dept Psychol, 152 Frelinghuysen Rd, Piscataway, NJ 08854 USA Rutgers State Univ 152 Frelinghuysen Rd Piscataway NJ USA 08854 SA
Citazione:
C.E. Lau et al., "Pharmacokinetic determinants of cocaine's differential effects on locomotor and operant behavior", EUR J PHARM, 381(2-3), 1999, pp. 85-92

Abstract

Dose-response, effect-time and concentration-effect relations of intravenous cocaine (1-4 mg/kg) were investigated on contingency-controlled [fixed-ratio (FR) 70 performance] and unconditioned (locomotor activity) behaviors. Cocaine dose-response curves exhibited decreasing rates of response under the FR 70 schedule but increasing locomotor activity in a dose-related fashion. Effect-time profiles confirmed that these changes were time-dependent and provided additional clarity by mirroring the biexponential decay of cocaine concentrations with time. The duration of action of cocaine was comparatively shorter on locomotor activity than on FR performance. We integratedeffect-time profiles of the two behaviors with concentration-time profilessimulated from our previously published pharmacokinetic parameters to derive cocaine's pharmacodynamic parameters. Classical inhibitory E-max and sigmoidal E-max models were used to describe cocaine's effects on FR performance and locomotor activity, respectively. Simultaneous pharmacokinetic-pharmacodynamic modeling reveals evidence of acute tolerance to cocaine in locomotor activity, as indicated by decreasing potency with dose, but not in contingency-controlled behavior. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:10:34