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Titolo:
Thymic dependence of invariant V alpha 14(+) natural killer-T cell development
Autore:
Tilloy, F; Di Santo, JP; Bendelac, A; Lantz, O;
Indirizzi:
Hop Necker Enfants Malad, INSERM, U25, F-75015 Paris, France Hop Necker Enfants Malad Paris France F-75015 U25, F-75015 Paris, France Hop Necker Enfants Malad, INSERM, U429, Paris, France Hop Necker Enfants Malad Paris France alad, INSERM, U429, Paris, France Princeton Univ, Princeton, NJ 08544 USA Princeton Univ Princeton NJ USA 08544 ceton Univ, Princeton, NJ 08544 USA
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 10, volume: 29, anno: 1999,
pagine: 3313 - 3318
SICI:
0014-2980(199910)29:10<3313:TDOIVA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOGLOBULIN-E PRODUCTION; RECEPTOR-ALPHA-CHAIN; CLASS-I MOLECULES; BONE-MARROW; POSITIVE SELECTION; NKT CELLS; MICE; THYMOCYTES; CD4+; EXPRESSION;
Keywords:
common cytokine receptor gamma chain; CD1; T cell ontogeny; radiation chimera;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Lantz, O Hop Necker Enfants Malad, INSERM, U25, 155 Rue Sevres, F-75015 Paris, France Hop Necker Enfants Malad 155 Rue Sevres Paris France F-75015 nce
Citazione:
F. Tilloy et al., "Thymic dependence of invariant V alpha 14(+) natural killer-T cell development", EUR J IMMUN, 29(10), 1999, pp. 3313-3318

Abstract

Both thymic and extrathymic bone marrow (BM)-derived pathways for the development of CD1 reactive, V alpha 14-J alpha 281(+) NK1.1(+) T cells have been suggested. In this report, we sought evidence for extrathymic NK-T cell development using two approaches. First, BM cells from gamma c-deficient mice were examined for the presence of V alpha 14-J alpha 281 transcripts. Since intrathymic NK-T cell selection is gamma c independent, we predicted that gamma c(-) BM cells should also harbor these specific TCR alpha chains. Second, V alpha 14-J alpha 281 transcripts were analyzed in BM cells from lethally irradiated, thymectomized mice reconstituted with fetal liver hematopoietic precursors. All donor-derived T cell development in these chimerasis by definition extrathymic. In both cases, we failed to detect invariantV alpha 14(+) TCR alpha chain transcripts. These experiments call into question the significance of an extrathymic pathway of development for V alpha14(+) NK1.1(+) CD1-reactive T cells.

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Documento generato il 23/09/20 alle ore 16:09:46