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Titolo:
Acute effects of inhalable particles on the frog palate mucociliary epithelium
Autore:
Macchione, M; Oliveira, AP; Gallafrio, C; Muchao, FB; Obara, MT; Guimaraes, ET; Artaxo, P; King, M; Lorenzi, G; Junqueira, VCB; Saldiva, PHN;
Indirizzi:
Univ Sao Paulo, Sch Med, Fac Med, Lab Poluicao Atmosfer Expt, BR-01246903 Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil BR-01246903 BC01246903 Sao Paulo, Brazil HC FMUSP, Inst Coracao, Sao Paulo, Brazil HC FMUSP Sao Paulo BrazilHC FMUSP, Inst Coracao, Sao Paulo, Brazil USP, Dept Bioquim, Inst Quim, BR-09500900 Sao Paulo, Brazil USP Sao Paulo Brazil BR-09500900 BCt Quim, BR-09500900 Sao Paulo, Brazil USP, Inst Fis, Grp Estudos Poluicao Ar, BR-09500900 Sao Paulo, Brazil USPSao Paulo Brazil BR-09500900 BCcao Ar, BR-09500900 Sao Paulo, Brazil Univ Alberta, Dept Med, Pulm Res Grp, Edmonton, AB, Canada Univ Alberta Edmonton AB Canada Med, Pulm Res Grp, Edmonton, AB, Canada UNIFESP, Ctr Estudios Envelhecimento, Sao Paulo, Brazil UNIFESP Sao Paulo Brazil Ctr Estudios Envelhecimento, Sao Paulo, Brazil
Titolo Testata:
ENVIRONMENTAL HEALTH PERSPECTIVES
fascicolo: 10, volume: 107, anno: 1999,
pagine: 829 - 833
SICI:
0091-6765(199910)107:10<829:AEOIPO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSEPITHELIAL POTENTIAL DIFFERENCE; AIR-POLLUTION; URBAN LEVELS; SAO-PAULO; MUCUS; CLEARANCE; TRANSPORT; EXPOSURE; BRAZIL; RATS;
Keywords:
air pollution; cilia beat frequency; glutathione; mucociliary transport; morphometric analyses;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Saldiva, PHN Univ Sao Paulo, Sch Med, Fac Med, Lab Poluicao Atmosfer Expt,Av Dr Arnaldo 455, BR-01246903 Sao Paulo, Brazil Univ Sao Paulo Av Dr Arnaldo 455 Sao Paulo Brazil BR-01246903 BC
Citazione:
M. Macchione et al., "Acute effects of inhalable particles on the frog palate mucociliary epithelium", ENVIR H PER, 107(10), 1999, pp. 829-833

Abstract

This work was designed to evaluate the toxicity of inhalable particles less than or equal to 10 pm in aerodynamic diameter (PM10) collected from the urban air in Sao Paulo, Brazil, to the mucociliary apparatus using the frogpalate preparation. Seven groups of frog palates were immersed in different concentrations of PM10 diluted in Ringer's solution during 120 min: 0 (control, n = 31); 50 (n = 10); 100 (n = 9); 500 (n = 28); 1,000 (n = 10); 5,000 (n = 11); and 10,000 mu g/m(3) (n = 10). Mucociliary transport and transepithelial potential difference were determined at 0, 30, 60, and 120 min exposure. Additional groups (control and 500 pg/m(3)) were studied by means of morphometric analyses (quantification of the amount of intraepithelial and surface mucins), measurement of cilia beat frequency, and quantificationof total glutathione. Mucociliary transport and transepithelial potential difference were significantly decreased at higher concentrations of PM10 (p= 0.03 and p = 0.02, respectively). Exposure to PM10 also elicited a significant decrease of total glutathione (p = 0.003) and depletion of neutral intraepithelial mucins (p = 0.0461). These results show that PM10 can promote significant alterations in ciliated epithelium in vitro.

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Documento generato il 14/07/20 alle ore 02:49:22