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Titolo:
Deletion of the ryanodine receptor type 3 (RyR3) impairs forms of synapticplasticity and spatial learning
Autore:
Balschun, D; Wolfer, DP; Bertocchini, F; Barone, V; Conti, A; Zuschratter, W; Missiaen, L; Lipp, HP; Frey, JU; Sorrentino, V;
Indirizzi:
San Raffaele Sci Inst, DIBIT, I-20132 Milan, Italy San Raffaele Sci Inst Milan Italy I-20132 t, DIBIT, I-20132 Milan, Italy Leibniz Inst Neurobiol, Magdeburg, Germany Leibniz Inst Neurobiol Magdeburg Germany Neurobiol, Magdeburg, Germany Univ Zurich, Inst Anat, CH-8006 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8006 Anat, CH-8006 Zurich, Switzerland Katholieke Univ Leuven, Dept Physiol, Louvain, Belgium Katholieke Univ Leuven Louvain Belgium , Dept Physiol, Louvain, Belgium Univ Siena, Dept Biomed Sci, I-53100 Siena, Italy Univ Siena Siena ItalyI-53100 na, Dept Biomed Sci, I-53100 Siena, Italy
Titolo Testata:
EMBO JOURNAL
fascicolo: 19, volume: 18, anno: 1999,
pagine: 5264 - 5273
SICI:
0261-4189(19991001)18:19<5264:DOTRRT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; LOW-FREQUENCY STIMULATION; CA2+ RELEASE CHANNELS; MORRIS WATER MAZE; RAT DENTATE GYRUS; POSTSYNAPTIC CALCIUM; PROTEIN-SYNTHESIS; SKELETAL-MUSCLES; MUTANT MICE; IN-VITRO;
Keywords:
behavior; calcium release channels; ryanodine receptor type 3; spatial learning; synaptic plasticity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Sorrentino, V San Raffaele Sci Inst, DIBIT, Via Olgettina 58, I-20132 Milan, Italy San Raffaele Sci Inst Via Olgettina 58 Milan Italy I-20132
Citazione:
D. Balschun et al., "Deletion of the ryanodine receptor type 3 (RyR3) impairs forms of synapticplasticity and spatial learning", EMBO J, 18(19), 1999, pp. 5264-5273

Abstract

Deletion of the ryanodine receptor type 3 (RyR3) results in specific changes in hippocampal synaptic plasticity, without affecting hippocampal morphology, basal synaptic transmission or presynaptic function. Robust long-termpotentiation (LTP) induced by repeated, strong tetanization in the CA1 region and in the dentate gyrus was unaltered in hippocampal slices iii vitro,whereas weak forms of plasticity generated by either a single weak tetanization or depotentiation of a robust LTP were impaired. These distinct physiological deficits were paralleled by a reduced flexibility in relearning a new target in the water-maze. In contrast, learning performance in the acquisition phase and during probe trial did not differ between the mutants andtheir wild-type littermates. In the open-field, RyR3(-/-) mice displayed anormal exploration and habituation, but had an increased speed of locomotion and a mild tendency to circular running. The observed physiological and behavioral effects implicate RyR3-mediated Ca2+ release in the intracellular processes underlying spatial learning and hippocampal synaptic plasticity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:05:52