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Titolo:
CD10 PLAYS A SPECIFIC ROLE IN EARLY THYMIC DEVELOPMENT
Autore:
GUERIN S; MARI B; MAULON L; BELHACENE N; MARGUET D; AUBERGER P;
Indirizzi:
FAC MED NICE,CJF INSERM 9605,AVE VALLOMBROSE F-06107 NICE 02 FRANCE FAC MED NICE,CJF INSERM 9605 F-06107 NICE 02 FRANCE CIML,INSERM U136 F-13288 MARSEILLE 09 FRANCE
Titolo Testata:
The FASEB journal
fascicolo: 5, volume: 11, anno: 1997,
pagine: 376 - 381
SICI:
0892-6638(1997)11:5<376:CPASRI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOPEPTIDASE 24.11 ENKEPHALINASE; LEUKEMIA ANTIGEN CALLA; THYMOPOIETIN; PROGENITORS; ACTIVATION; INHIBITION; HORMONES; ENZYMES; MICE;
Keywords:
FLOW CYTOMETRY; FTOC; THYMOPENTIN; THYMIC EPITHELIAL CELLS; ENDOPEPTIDASE 24.11;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
S. Guerin et al., "CD10 PLAYS A SPECIFIC ROLE IN EARLY THYMIC DEVELOPMENT", The FASEB journal, 11(5), 1997, pp. 376-381

Abstract

Development of T lymphocyte is a complex process that depends on boththymocyte-stromal cell interactions and the production of soluble factors such as cytokines, peptides, and hormones. In many tissues, the concentration of active biological peptides is regulated locally by a specialized family of enzymes: the ectopeptidases. We show here that treatment of fetal thymic organ cultures (FTOC) with the specific CD10 (endopeptidase 24.11)inhibitors SCH 32615: boxy-2-phenyl)ethyl]-L-phenylalanyl-beta-alanine), RB25: o)carbonyl]-2-benzylidene-1-oxopropyl]-N-glycine), and thymopentin (TP5) results in the inhibition of thymocytedifferentiation. Each agent induces a significant decrease in the number of double positive (CD4(+) CD8(+)) cells in favor of the TN (TcR alpha beta(-)CD4(-)Cd8(-)) population. RB25 also blocks T lymphocyte differentiation in FTOC when preinjected into pregnant mice. Finally, RB25 and TP5 were also shown to reduce the number of CD44(+)CD25(-) and CD44(-)CD25(-) thymocytes both in vitro and after preinjection in vivoin day 2 FTOC. Thus, agents that affect endopeptidase 24.11 activity impair T cell development both in vitro and in vivo. Our results show that the CD10 molecule plays a specific role in promoting early T celldevelopment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:14:31