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Titolo:
Scintigraphic prediction of resistance to radiation and chemotherapy in patients with lung carcinoma - Technetium 99m-tetrofosmin and thallium-201 dual single photon emission computed tomography study
Autore:
Fukumoto, M; Yoshida, D; Hayase, N; Kurohara, A; Akagi, N; Yoshida, S;
Indirizzi:
Kochi Med Sch, Dept Radiol, Nankoku, Kochi 7838505, Japan Kochi Med Sch Nankoku Kochi Japan 7838505 , Nankoku, Kochi 7838505, Japan
Titolo Testata:
CANCER
fascicolo: 8, volume: 86, anno: 1999,
pagine: 1470 - 1479
SICI:
0008-543X(19991015)86:8<1470:SPORTR>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER CELL-LINE; P-GLYCOPROTEIN; MULTIDRUG-RESISTANCE; BREAST-CANCER; MYOCARDIAL PERFUSION; TC-99M SESTAMIBI; DRUG-RESISTANCE; TL-201 UPTAKE; TUMOR-CELLS; ISOTOPE;
Keywords:
single photon emission computed tomography; thallium-201; technetium-99m; tetrofosmin; lung carcinoma; prediction; multidrug resistance; radioresistance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Fukumoto, M Kochi Med Sch, Dept Radiol, Nankoku, Kochi 7838505, Japan Kochi Med Sch Nankoku Kochi Japan 7838505 ochi 7838505, Japan
Citazione:
M. Fukumoto et al., "Scintigraphic prediction of resistance to radiation and chemotherapy in patients with lung carcinoma - Technetium 99m-tetrofosmin and thallium-201 dual single photon emission computed tomography study", CANCER, 86(8), 1999, pp. 1470-1479

Abstract

BACKGROUND. Various prognostic markers for lung carcinoma have been proposed, but to the authors' knowledge none is noninvasive and convenient for clinical use. The current study examined the utility of several radiotracers for the prediction of multidrug resistance (MDR) and radioresistance in patients with lung carcinoma. METHODS, Thirty patients with untreated lung carcinoma underwent a dual isotope single photon emission computed tomography (SPECT) scan at 10 minutesand 120 minutes after the injection of technetium-99m (Tc-99m)-tetrofosmin(Tc-99m-TF) (370 megabecquerels [MBq]) and thallium-201 ((TlCl)-Tl-201) (111 MBq). Retention of each tracer was evaluated semiquantitatively. Using radiation and chemotherapy (cisplatin plus etoposide), the patients either were treated sequentially (n = 12) or concurrently (n = 18). The relation between therapeutic response and retention of each tracer was analyzed. The detectability of radioresistance was examined. RESULTS. In patients treated with sequential therapy, the response to radiation was predicted by 99mTc-TF retention, whereas Tl-201 retention was found not to be predictive. Regardless of whether the sequential or concurrentprotocol was applied, 14 of 18 tumors with high 99mTc-TF retention (greater than or equal to 15%) exhibited a favorable response to chemoradiotherapywhereas all 12 tumors with low Tc-99m-Tf retention (less than or equal to 15%) did not respond to the therapy. In contrast, Tl-201 retention was not found to be a predictive factor. CONCLUSIONS. The employed SPECT method is a useful tool for the in vivo prediction of radioresistance, P-glycoprotein (P-gp), and non-P-gp MDR in lung carcinoma. Low Tc-99m-TF retention serves as a strong predictor of therapeutic resistance. High 99mTc-TF retention implies a favorable response. Tl-201 did not appear to be a predictive factor but is required for localization of the lesion on SPECT imaging. (C) 1999 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:19:58