Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IDENTIFICATION OF DYSPLASIA IN HUMAN COLONIC ABERRANT CRYPT FOCI
Autore:
SIU IM; PRETLOW TG; AMINI SB; PRETLOW TP;
Indirizzi:
CASE WESTERN RESERVE UNIV,MED CTR,INST PATHOL B30,2085 ADELBERT RD CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,MED CTR,INST PATHOL B30 CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,MED CTR,DEPT BIOSTAT & EPIDEMIOL CLEVELAND OH 44106
Titolo Testata:
The American journal of pathology
fascicolo: 5, volume: 150, anno: 1997,
pagine: 1805 - 1813
SICI:
0002-9440(1997)150:5<1805:IODIHC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PUTATIVE PRENEOPLASTIC LESIONS; F344 RATS; ANTIGEN; MUTATIONS; CANCER; QUANTIFICATION; CLASSIFICATION; MICROADENOMAS; ADENOMAS; APC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
I.M. Siu et al., "IDENTIFICATION OF DYSPLASIA IN HUMAN COLONIC ABERRANT CRYPT FOCI", The American journal of pathology, 150(5), 1997, pp. 1805-1813

Abstract

Aberrant crypt foci (ACF) are grossly invisible putative premalignantlesions in the colon. As dysplasia is considered an important precursor of colon carcinoma, we wanted to determine the presence and severity of dysplasia in human ACF. Fifty ACF from 28 patients were embedded in paraffin, cut serially, and stained with hematoxylin and eosin. Multiple slides from each ACF were evaluated for dysplasia according to adefined set of criteria. Of 50 ACF, 3 (6%) contained focal areas withsevere dysplasia, ie. carcinoma in situ, 4 (8%) contained focal areaswith moderate dysplasia, and 20 (40%) contained focal areas with milddysplasia. Twenty-three ACF (46%) contained no detectable dysplasia. In 15 of 27 ACF with dysplasia, less than 50% (eg, 4 of 28, 10 of 54, and 10 of 30 sections) of the sections cut and evaluated from each ACFdemonstrated dysplasia. The presence of dysplasia in a large proportion of ACF supports the hypothesis that they may be precarcinomatous.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 13:37:07