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Titolo:
TISSUE INHIBITOR OF METALLOPROTEINASE-1 AND METALLOPROTEINASE-2 RNA EXPRESSION IN RAT AND HUMAN LIVER FIBROSIS
Autore:
HERBST H; WEGE T; MILANI S; PELLEGRINI G; ORZECHOWSKI HD; BECHSTEIN WO; NEUHAUS P; GRESSNER AM; SCHUPPAN D;
Indirizzi:
UNIV HAMBURG,HOSP EPPENDORF,INST PATHOL,MARTINISTR 52 D-20246 HAMBURGGERMANY FREE UNIV BERLIN,KLINIKUM BENJAMIN FRANKLIN,INST PATHOL D-12200 BERLIN GERMANY FREE UNIV BERLIN,KLINIKUM BENJAMIN FRANKLIN,DEPT GASTROENTEROL D-12200 BERLIN GERMANY HUMBOLDT UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW,DEPT SURG BERLIN GERMANY UNIV MARBURG,DEPT CLIN CHEM D-3550 MARBURG GERMANY UNIV FLORENCE,DEPT CLIN PATHOPHYSIOL,GASTROENTEROL UNIT FLORENCE ITALY
Titolo Testata:
The American journal of pathology
fascicolo: 5, volume: 150, anno: 1997,
pagine: 1647 - 1659
SICI:
0002-9440(1997)150:5<1647:TIOMAM>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAT-STORING CELLS; TRANSFORMING GROWTH FACTOR-BETA-1; IV COLLAGENASE; EXTRACELLULAR-MATRIX; MESSENGER-RNA; POTENTIATING ACTIVITY; 72-KDA PROGELATINASE; HUMAN-FIBROBLASTS; SPATIAL PATTERNS; GENE-EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
H. Herbst et al., "TISSUE INHIBITOR OF METALLOPROTEINASE-1 AND METALLOPROTEINASE-2 RNA EXPRESSION IN RAT AND HUMAN LIVER FIBROSIS", The American journal of pathology, 150(5), 1997, pp. 1647-1659

Abstract

The remodeling of extracellular matrix during chronic liver disease may partially be attributed to altered activity of matrix metalloproteinases and their tissue inhibitors (TIMPs). Expression of TIMP-1 and -2was studied by in situ hybridization combined with immunohistochemistry in rat (acute and chronic carbon tetrachloride intoxication and secondary biliary fibrosis) and human livers and on isolated rat hepatic stellate cells. TIMP-1 and -2 transcripts appeared in rat livers within 1 to 3 hours after intoxication, pointing to a role in the protection against accidental activation of matrix metalloproteinases, and werepresent at high levels in all fibrotic rat and human livers predominantly in stellate cells. TIMP-2 RNA distribution largely matched with previously reported patterns of matrix metalloproteinase-2 (72-kd gelatinase) expression, suggesting generation of a TIMP-2/matrix metalloproteinase-2 complex (large inhibitor of metalloproteinase). Isolated stellate cells expressed TIMP-1 and -2 RNA. Addition of transforming growth factor-beta 1 enhanced TIMP-1 and matrix metalloproteinase-2 RNA levels in vitro, whereas TIMP-2-specific signals were reduced, likely toresult in a stoichiometric excess of matrix-metalloproteinase-2 over TIMP-2. In the context of previous demonstrations of transforming growth factor-beta 1 and matrix metalloproteinase-2 in vivo, these patterns suggest an intrahepatic environment permitting only limited matrix degradation, ultimately resulting in redistribution of extracellular matrix with relative accumulation of collagen type I.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:49:45