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Titolo:
NMDA receptor-mediated control of GABA release from neurointermediate lobes of female and male rats
Autore:
Pampillo, M; De Laurentiis, A; Duvilanski, B; Pisera, D; Diaz, MD; Seilicovich, A; Lasaga, M;
Indirizzi:
Univ Buenos Aires, Fac Med, Ctr Invest Reprod, RA-1121 Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina RA-1121 Aires, DF, Argentina
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 842, anno: 1999,
pagine: 469 - 472
SICI:
0006-8993(19990925)842:2<469:NRCOGR>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY AMINO-ACIDS; NITRIC-OXIDE; DOPAMINERGIC-NEURONS; GLUTAMATE; REPRODUCTION; HYPOTHALAMUS; CEREBELLUM; SECRETION; CGMP;
Keywords:
N-methyl-D-aspartate; GABA release; neurointermediate lobe;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Lasaga, M Univ Buenos Aires, Fac Med, Ctr Invest Reprod, Piso 10, RA-1121 Buenos Aires, DF, Argentina Univ Buenos Aires Piso 10 Buenos Aires DF Argentina RA-1121 tina
Citazione:
M. Pampillo et al., "NMDA receptor-mediated control of GABA release from neurointermediate lobes of female and male rats", BRAIN RES, 842(2), 1999, pp. 469-472

Abstract

The effect of glutamate (GLUT) and its ionotropic receptor agonists on K+-evoked GABA release from the neurointermediate lobe (NIL) was investigated in diestrus, ovariectomized, ovariectomized-estrogenized female rats and intact male rats. GLUT and N-methyl-D-aspartate (NMDA) increased K+-evoked GABA release from the NIL in all the experimental groups. This stimulatory effect of NMDA was blocked by specific NMDA receptor antagonists but not by non-NMDA receptor antagonists. However, kainate did not modify evoked GABA release from the NIL, in any of these groups. Neither GLUT nor NMDA modifiednitric oxide synthase activity. These results indicate that GLUT, acting through NMDA receptors, stimulates evoked GABA release from the Na of femaleand male rats. This effect is not influenced by gonadal status and does not appear to be mediated by nitric oxide production. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:07:10